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Phage display technology in ecotoxicology: phage display derived unique peptide for copper identification in aquatic samples.
Microb Cell Fact
January 2025
Department of in Vitro Studies, Institute of Biotechnology and Molecular Medicine, Kampinoska 25, 80-180, Gdańsk, Poland.
Background: Ecotoxicology is essential for the evaluation and comprehension of the effects of emergency pollutants (EP) such as heavy metal ions on the natural environment. EPs pose a substantial threat to the health of humans and the proper functioning of the global ecosystem. The primary concern is the exposure of humans and animals to heavy metal ions through contaminated water.
View Article and Find Full Text PDFCancer continues to represent a substantial burden in terms of its morbidity and mortality, underscoring the imperative for the development of novel and efficacious treatment modalities. Recent advances in cancer immunotherapy have highlighted the importance of identifying tumour-specific antigens, which can assist the immune system in targeting malignant cells effectively. Phage display technology has emerged as an effective tool for the discovery of novel antigens through cDNA library screening, representing a significant advancement in the field of immunological research.
View Article and Find Full Text PDFDual-Engineered Phage Vaccine Platform Facilitates STING Activation for Influenza Protection.
ACS Appl Mater Interfaces
January 2025
Department of Cardiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362400, China.
Influenza epidemics remain a global public health challenge. Vaccination with nucleic acid-based vaccines, which trigger strong cellular and humoral immune responses, represents a promising approach for preventing virus infection. However, its effectiveness relies on efficient delivery and an immunoadjuvant.
View Article and Find Full Text PDFUnveiling the Sorption Properties of Graphene Oxide-M13 Bacteriophage Aerogels for Advanced Sensing and Environmental Applications.
ACS Appl Mater Interfaces
December 2024
School of Chemical Engineering, Advanced Nanomaterials Structures and Applications Laboratories, College of Engineering and Physical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
GraPhage13 aerogels (GPAs) are ultralow density, porous structures fabricated through the self-assembly of graphene oxide (GO) and M13 bacteriophage. Given GPA's high surface area and extensive porous network, properties typically associated with highly adsorbent materials, it is essential to characterize its sorption capabilities, with a focus on unlocking its potential for advanced applications in areas such as biomedical sensing and environmental monitoring. Herein, the water, ethanol and acetone sorption properties of GPA were explored using dynamic vapor sorption (DVS).
View Article and Find Full Text PDFExploring multivalency-driven sensitivity modulation for optimization and fine-tuning of avidity-based biosensors.
Biosens Bioelectron
March 2025
Department of Biochemistry, Kangwon National University, Chuncheon, 24341, South Korea; Institute of Life Sciences (ILS), Kangwon National University, Chuncheon, 24341, South Korea; Global/Gangwon Innovative Biologics-Regional Leading Research Center (GIB-RLRC), Kangwon National University, Chuncheon, 24341, South Korea. Electronic address:
The development of multivalent nanoprobes has garnered considerable interest due to their enhanced sensitivity and precision in diagnosing and monitoring diverse diseases. Despite significant advances in nanobiotechnology, the optimal density of binding motifs to maximize the diagnostic efficacy of biosensors remains incompletely understood. Herein, we investigate the influence of multivalency in the functional performance of avidity-based biosensors.
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