Thirty-four patients with diminutive peripheral veins requiring peripheral IV access (PIVA) in the emergency department setting were randomly assigned to one of two treatment groups. One group of patients (Group A) received application of a bland ointment to the dorsum of the hand prior to attempts at cannulation, while the other group (Group B) received application of 2% nitroglycerin ointment to the dorsum of the hand prior to cannulation attempts. Cannulation was achieved in all 34 patients in the study, but required significantly fewer attempts in Group B patients (P = .04). No side effects of the drug were observed in any patient or any staff member applying the ointments. We conclude that application of 2% nitroglycerin ointment to the dorsum of the hand is a safe, effective method of inducing local venodilation that will ensure PIVA with significantly fewer attempts at cannulation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0196-0644(87)80682-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Chuanxiong Qingnao Granules (CQG) alleviates nitroglycerin-induced migraine-like pain in rats by glycerophospholipid metabolism and PI3K/Akt signaling pathway.
Phytomedicine
December 2024
Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China. Electronic address:
Background And Purpose: Chuanxiong Qingnao Granles (CQG), has been used to treat migraine headache (MH) for many years. However, current investigation of CQG have primarily focused on clinical studies, and the potential mechanisms underlying of its effects on MH have not been fully elucidated. In the present study, we applied an integrated approach of transcriptomics and metabolomics to elucidate the therapeutic mechanisms of CQG in nitroglycerin (NTG)-induced MH injury.
View Article and Find Full Text PDFWord of caution: clinically apparent coronary spasm following pulsed field cavotricuspid isthmus ablation despite nitroglycerin prophylaxis - a case report.
Eur Heart J Case Rep
November 2024
Department of Cardiology and Intensive Care Medicine, Asklepios Hospital St. Georg, Lohmühlenstr. 5, Hamburg 20099, Germany.
Background: Pulsed field ablation (PFA) is a novel ablation technology. A rare side-effect is the occurrence of mostly subclinical coronary spasms when PF energy is applied in proximity to coronary arteries. However, it has been described that prior application of nitroglycerin attenuates these effects.
View Article and Find Full Text PDFEffects of ligustrazine on energy metabolism in migraine rats based on mitochondria-inflammation pathway.
Neurosci Lett
January 2025
Department of Neurology, The Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, China. Electronic address:
Article Synopsis
- - The study aimed to assess how Ligustrazine (Lig) affects migraines triggered by nitroglycerin and to investigate the mechanisms involved, particularly focusing on the mitochondria-inflammation pathway.
- - Using rat models, researchers divided subjects into different treatment groups and measured various factors including pain thresholds, mitochondrial health, and levels of inflammatory markers, revealing that Lig improved outcomes compared to a control group.
- - Results indicated that Lig has anti-migraine effects by reducing inflammation and oxidative stress related to mitochondrial function, highlighting its potential for future migraine treatment strategies.
Zolmitriptan niosomal transdermal patches: combating migraine via epigenetic and endocannabinoid pathways and reversal of migraine hypercoagulability.
Drug Deliv Transl Res
November 2024
Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Pharos University in Alexandria, Alexandria, 21648, Egypt.
Conventional zolmitriptan (ZOL) has limited oral bioavailability, many adverse effects, and poor membrane penetrability that negatively influences its accessibility to its 5-HT receptor binding pocket, located transmemberanous. This work aimed at preparing transdermal ZOL-nanoformulation (niosomes) to surpass these limitations and to explore novel antimigraine mechanisms for ZOL via modulation of the epigenetically-altered chronification genes (RAMP-1, NPTX-2) or microRNAs and affecting the endocannabinoid CB-1/MAPK pathway. The prepared ZOL niosomes (F) exhibited %EE of 57.
View Article and Find Full Text PDFThe search for non-evoked markers of pain in the GTN mouse model of migraine.
Sci Rep
November 2024
Department of Neurology, Danish Headache Center, Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark.
Rodent migraine models have been developed to study the underlying molecular mechanisms of migraine, but these need further development and validation to stay relevant. The glyceryl trinitrate (GTN) mouse model with tactile hypersensitivity as the primary readout, has been highly used to understand the pathophysiology of migraine. Nevertheless, this readout has questionable translatability to the experience of spontaneous pain and additional readouts are needed to improve this model.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!