We report on the experimental generation of broad and flat optical frequency combs (OFC) in a 1550 nm laser diode using gain switching with pulsed electrical excitation together with optical injection. The combination of both techniques allows the generation of high-quality OFCs at a repetition frequency of 500 MHz, showing a low-noise optical spectrum with unprecedent features in terms of width (108 tones within 10 dB) and flatness (56 tones within 3 dB) in comparison with those previously reported for this modulation frequency. The influence of the injection conditions on the OFC quality is studied. Using these two techniques, it has been possible to reduce the separation between tones, generating high spectral performance OFCs with a repetition rateof 100 MHz.
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http://dx.doi.org/10.1364/OE.27.009155 | DOI Listing |
Nutrients
February 2025
Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
: The objective of this study was to analyze the relationships between diet and geographic atrophy (GA) progression, both area-based and proximity-based, for dietary pattern, components, and micronutrients. : In the Age-Related Eye Diseases Study (AREDS) and AREDS2, an Alternative Mediterranean Diet Index (aMedi), its nine components, and individual micronutrient intakes were calculated. Mixed-model regression was performed for square root GA area, GA foveal proximity, and acuity.
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February 2025
Institute of Electronics, Bulgarian Academy of Sciences, 72 Tzarigradsko Chaussee, Blvd., 1784 Sofia, Bulgaria.
Silk fibroin (SF), the primary protein in silkworm silk, has emerged as a promising organic nonlinear optical material due to its unique combination of optical transparency, biocompatibility, and environmental sustainability. In this study, we investigate the nonlinear optical properties of SF thin films using the -scan technique with femtosecond laser pulses (35 fs, 800 nm, 1 kHz). Our results reveal a strong self-defocusing effect (negative nonlinear refractive index) and significant multiphoton absorption, demonstrating SF's tunable nonlinear response.
View Article and Find Full Text PDFCancers (Basel)
February 2025
Department of Neuro-Oncology, Princess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands.
The current standard therapy for pediatric optic pathway/hypothalamic glioma (OPHG) is systemic anticancer therapy (SAT) over surgery and radiotherapy. Nevertheless, recurrent radiological or clinical tumor progression after SAT forms a considerable challenge. Sporadic OPHGs are considered to have a higher tendency toward progression after first-line systemic anticancer therapy (SAT) compared to neurofibromatosis type-1-associated (NF1) OPHGs.
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March 2025
The Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, China.
This study aimed to explore the relationship between biochemical profiles and the risk of age-related macular degeneration (AMD) through a cross-sectional observational analysis. We examined data of U. S.
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March 2025
Jiangyin People's Hospital Affiliated to Southeast University, Jiangyin, China.
This study aims to explore potential adverse events (AEs) related to Dupilumab using data from the US FDA Adverse Event Reporting System (FAERS) database. The FAERS database from Q2 2017 to Q4 2023 was mined for AEs related to Dupilumab. The types of AEs reported, along with gender, age distribution, and severity, were evaluated.
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