New Diketopiperazines from a Marine-Derived Fungus Strain MF180151.

Six new diketopiperazines, (±)-7,8-epoxy-brevianamide Q ((±)-), (±)-8-hydroxy-brevianamide R ((±)-), and (±)-8-epihydroxy-brevianamide R ((±)-), together with four known compounds, (±)-brevianamide R ((±)-), versicolorin B () and averufin (), were isolated from a marine-derived fungus strain MF180151, which was recovered from a sediment sample collected from the Bohai Sea, China. The chemical structures were established by 1D- and 2D-NMR spectra and HR-ESI-MS. is the first sample of brevianamides with an epoxy moiety. Their bioactivities were evaluated against s, , , methicillin-resistant , , and Bacillus Calmette-Guérin. Compounds - showed no activities against the pathogens, and compounds and showed moderate activities against and methicillin-resistant .