The effect of saturated fatty acids (SFAs) on incident type 2 diabetes (T2D) is controversial and few have systematically appraised the evidence. We conducted a comprehensive search of prospective studies examining these relationships that were published in PubMed, Web of Science, or EMBASE from 21 February 1989 to 21 February 2019. A total of 19 studies were included for systematic review and 10 for meta-analysis. We estimated the summarized relative risk (RR) and 95% confidence interval (95% CI) using a random (if I > 50%) or a fixed effects model (if I ≤ 50%). Although the included studies reported inconclusive results, the majority supported a protective effect of odd-chain and an adverse impact of even-chain SFAs. Meta-analysis showed that the per standard deviation (SD) increase in odd-chain SFAs was associated with a reduced risk of incident T2D (C15:0: 0.86, 0.76-0.98; C17:0: 0.76, 0.59-0.97), while a per SD increase in one even-chain SFA was associated with an increased risk of incident T2D (C14:0: 1.13, 1.09-1.18). No associations were found between other SFAs and incident T2D. In conclusion, our findings suggest an overall protective effect of odd-chain SFAs and the inconclusive impact of even- and very-long-chain SFAs on incident T2D.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566227 | PMC |
| http://dx.doi.org/10.3390/nu11050998 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Association of family history of cardiovascular disease with the prevalence of cardiometabolic risk factors in young adults in the United Arab Emirates: The UAE healthy future study.
PLoS One
March 2025
Public Health Research Center, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates.
Introduction: Family history of cardiovascular disease (CVD) is an independent risk factor for coronary heart disease, and the risk increases with number of family members affected. It offers insights into shared genetic, environmental and lifestyle factors that influence heart disease risk. In this study, we aimed to estimate the association of family history of CVD and its risk factors, as well as the number of affected parents or siblings, with the prevalence of major cardiometabolic risk factors (CRFs) such as hypertension, dysglycemia, dyslipidemia and obesity in a sample of young adults.
View Article and Find Full Text PDFGenetic Susceptibility to Type 2 Diabetes, Television Viewing, and Atherosclerotic Cardiovascular Disease Risk.
J Am Heart Assoc
March 2025
Background: Type 2 diabetes (T2D) is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). This study examined the interplay between watching television and T2D genetic risk for risk of ASCVD.
Methods: We included 346 916 White British individuals from UK Biobank.
The Association of Levels of Food Insecurity and Disordered Eating Behaviors Among Youth and Young Adults With Diabetes: The SEARCH for Diabetes in Youth Study.
Int J Eat Disord
March 2025
Fred Hutchinson Cancer Center, University of Washington, Seattle Children's Research Institute, Seattle, Washington, USA.
Objective: To examine the relationship between levels of household food insecurity and disordered eating behaviors (DEB) among youth and young adults with youth-onset type 1 (T1D) and type 2 diabetes (T2D).
Method: We used cross-sectional data from the multicenter SEARCH for Diabetes in Youth Study (2015-2020). The Household Food Security Survey Module and the Diabetes Eating Problem Survey-Revised (DEPS-R) were utilized to measure household food insecurity and continuous scores for DEB.
Positive causal association between diabetes and osteomyelitis, mediated by glycosylated hemoglobin and BMI: Evidence from a Mendelian randomization study.
Medicine (Baltimore)
March 2025
Department of Orthopedic, Xi'an Central Hospital, Xi'an, Shaanxi, China.
Diabetes mellitus (DM), a prevalent metabolic disorder, is intricately linked to various infectious diseases. Notably, osteomyelitis (OM), an infection affecting bone tissue, exhibits a higher incidence in individuals with DM. The primary objective of this study was to establish the causal association between DM and OM through Mendelian randomization (MR) analysis while also investigating potential mediating factors that may contribute to this relationship.
View Article and Find Full Text PDFBody Composition Differentiates Prediabetes Phenotype Clusters in the Diabetes Prevention Program Study.
J Clin Endocrinol Metab
March 2025
Department of Physiological Nursing, School of Nursing, University of California, San Francisco.
Context: Type 2 diabetes (T2D) remains a significant public health program, and current approaches to risk reduction fail to adequately prevent T2D in all individuals.
Objective: The purpose of this study was to apply clustering methods that include metabolic risk factors and body composition measures to identify and characterize prediabetes phenotypes and their relationships with treatment arm and incident T2D.
Design: Secondary analysis of the Diabetes Prevention Program clinical trial.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!