Bistachybotrysins F-J (1-5), five new phenylspirodrimane dimers with a central cyclopentanone core were isolated from Stachybotrys chartarum CGMCC 3.5365. The structures of 1-5 were elucidated through extensive spectroscopic data analysis, including 1D/2D NMR, HR-MS, and ECD spectra. Compounds 3-5 displayed moderate cytotoxic activity against the cell lines HCT116, NCI-H460, and HepG2 with IC values ranging from 9.1 to 12.2 μM, making them promising as lead compounds for drug research and discovery.
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| http://dx.doi.org/10.1016/j.fitote.2019.04.013 | DOI Listing |
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