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Objective study validity diagnostics: a framework requiring pre-specified, empirical verification to increase trust in the reliability of real-world evidence.
J Am Med Inform Assoc
January 2025
Coordinating Center, Observational Health Data Science and Informatics, New York City, NY 10032, United States.
Objective: Propose a framework to empirically evaluate and report validity of findings from observational studies using pre-specified objective diagnostics, increasing trust in real-world evidence (RWE).
Materials And Methods: The framework employs objective diagnostic measures to assess the appropriateness of study designs, analytic assumptions, and threats to validity in generating reliable evidence addressing causal questions. Diagnostic evaluations should be interpreted before the unblinding of study results or, alternatively, only unblind results from analyses that pass pre-specified thresholds.
Impact of hopelessness on migration intentions of nursing students: a path analysis.
BMC Nurs
January 2025
Department of Nursing, Faculty of Health Sciences, Gaziantep Islam Science and Technology University, Gaziantep, Turkey.
Background: Brain drain refers to the migration of qualified professionals to developed countries in search of better living and working conditions, and has become a global concern, particularly in the healthcare sector. Migration of highly skilled nurses results in increased workload for the remaining nursing staff, limited access to quality healthcare services, and contributes to disparities in healthcare. Therefore, nursing students represent a critical demographic group for understanding the drivers of brain drain in the healthcare sector.
View Article and Find Full Text PDFImplementing Namaste Care in nursing care homes for people with advanced dementia: a systematically constructed review with framework synthesis.
BMC Geriatr
January 2025
International Observatory on End of Life Care, Lancaster University, Lancaster, UK.
Background: Namaste Care is an intervention designed to improve the quality of life for people with advanced dementia by providing individualised stimulation and personalised activities in a group setting. Current evidence indicates there may be benefits from this intervention, but there is a need to explore the practical realities of its implementation, including potential barriers, enablers, and how it is delivered within the context of nursing care homes.
Objective: To systematically assess the factors involved in implementing Namaste Care for people with advanced dementia in nursing care homes.
Opportunities, challenges and risks of using artificial intelligence for evidence synthesis.
BMJ Evid Based Med
January 2025
Institute for Evidence in Medicine, Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany.
[Interventional studies on acute-on-chronic liver failure: challenges and opportunities].
Zhonghua Gan Zang Bing Za Zhi
December 2024
Fourth Department of Liver Disease, Beijing Youan Hospital, Beijing100069, China Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research, Beijing100069, China.
Acute-on-chronic liver failure (ACLF) is a kind of complex syndrome characterized by acute deterioration of liver function on the basis of chronic liver disease, accompanied by organ failure and a high mortality rate. The International Society for Hepatology has proposed different definitions, diagnostic criteria, and treatment guidelines, which have led to differences in the clinical management of ACLF and underestimated the burden of the disease. Currently, there is no specific treatment for ACLF, and the overall prognosis is still not ideal.
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