Four-Session Protocol Effectiveness in Reducing Cervical Dentin Hypersensitivity: A 24-Week Randomized Clinical Trial.

A single-blind randomized clinical trial was conducted to evaluate the effectiveness of desensitizing agents with different action mechanisms in reducing cervical dentin hypersensitivity (CDH) after four application sessions, with 24-week follow-up. Sixty patients with CDH were selected in the study and were allocated in three groups of treatment: Desensibilize KF 2%, Clinpro XT Varnish, and Photon Lase III (100 mW, 4 J/cm-1 J/cm each point, 10 sec per point with wavelength of 808 nm). There were four application sessions performed, with a 48-h interval between each one. The evaporative stimuli and visual analog scale were used to evaluate the CDH level at baseline, immediately after treatment, and at 2, 4, 8, and 24 weeks after the application. Mixed-model effects test was used for comparison (α = 0.05). All three groups showed significant reduction in CDH from baseline to each all-subsequent follow-up. All the groups maintained the CDH reduction, and presented no statistical differences between each other after treatment ( = 0.885), 2 ( = 0.857), 4 ( = 0.928), 8 ( = 0.206), and 24 weeks ( = 0.073) of follow-up. The four-session protocol was an effective approach in reduction of CDH (even after 24 weeks), regardless of desensitization mechanism.