AI Article Synopsis
- Superparamagnetic iron oxide nanoparticles (SPIONs) are used as MRI contrast agents, but many have been withdrawn due to poor performance.
- The study aimed to enhance the T2-weighted MRI contrast of SPIONs by clustering them within a chitosan amphiphile.
- This clustering significantly improved the relaxation ratio, leading to better contrast in MRI images, particularly highlighting liver vasculature when administered intravenously.
Article Abstract
Superparamagnetic iron oxide nanoparticles (SPIONs) have been used as magnetic resonance imaging (MRI) contrast agents; however, a number of T2-weighted imaging SPIONs have been withdrawn due to their poor clinical contrast performance. Our aim was to significantly improve SPION T2-weighted MRI contrast by clustering SPIONs within novel chitosan amphiphiles. Clustering SPIONs was achieved by encapsulation of hydrophobic-coated SPIONs with an amphiphilic chitosan polymer (GCPQ). Clustering increases the spin-spin () to spin-lattice () relaxation ratio () from 3.0 to 79.1, resulting in superior contrast. Intravenously administered clustered SPIONs accumulated only in the liver and spleen; with the reduction in T2 relaxation confined, in the liver, to the extravascular space, giving clear MRI images of the liver vasculature.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2217/nnm-2018-0370 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Multifunctional Nanoparticles as Radiosensitizers to Overcome Hypoxia-Associated Resistance in Cancer Radiotherapy.
Nanomaterials (Basel)
December 2024
Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
Hypoxia, a phenomenon that occurs when the oxygen level in tissues is lower than average, is commonly observed in human solid tumors. For oncological treatment, the hypoxic environment often results in radioresistance and chemoresistance. In this study, a new multifunctional oxygen carrier, carboxymethyl hexanoyl chitosan (CHC) nanodroplets decorated with perfluorohexane (PFH) and superparamagnetic iron oxide (SPIO) nanodroplets (SPIO@PFH-CHC), was developed and investigated.
View Article and Find Full Text PDFAnxiety of microbially synthesized FeO-SPIONs on embryonic/larval ontogeny in red tilapia (Oreochromis sp.).
Appl Microbiol Biotechnol
January 2025
National Institute of Oceanography and Fisheries (NIOF), Cairo, Egypt.
Iron oxide nanoparticles, recognized for their superparamagnetic properties, are promising for future healthcare therapies. However, their extensive use in medicine and electronics contributes to their discharge into our environments, highlighting the need for further research on their cellular damage effects on aquatic organisms. While the detrimental properties of other compounds have been stated in the early-life stages of fish, the cytotoxic consequences of superparamagnetic iron oxide nanoparticles (SPIONs) in these stages are still unexplored.
View Article and Find Full Text PDFAssessing the Comparative Efficacy of Sentinel Lymph Node Detection Techniques in Vulvar Cancer: Protocol for a Systematic Review and Meta-Analysis.
Life (Basel)
November 2024
Department of Obstetrics and Gynecology, Semmelweis University, 1082 Budapest, Hungary.
This systematic review and meta-analysis protocol aims to evaluate the comparative efficacy of different sentinel lymph node (SLN) detection techniques in the management of vulvar cancer. Vulvar cancer, though rare, predominantly affects older women and requires effective management strategies. The SLN technique has become a standard approach for early-stage cases, offering reduced morbidity compared to complete lymphadenectomy.
View Article and Find Full Text PDFTherapies against hematological malignancies using chimeric antigen receptors (CAR)-T cells have shown great potential; however, therapeutic success in solid tumors has been constrained due to limited tumor trafficking and infiltration, as well as the scarcity of cancer-specific solid tumor antigens. Therefore, the enrichment of tumor-antigen specific CAR-T cells in the desired region is critical for improving therapy efficacy and reducing systemic on-target/off-tumor side effects. Here, we functionalized human CAR-T cells with superparamagnetic iron oxide nanoparticles (SPIONs), making them magnetically controllable for site-directed targeting.
View Article and Find Full Text PDFMagnetic properties of different phases iron oxide nanoparticles prepared by micro emulsion-hydrothermal method.
Sci Rep
January 2025
Department of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11623, Saudi Arabia.
In this study, we report the synthesis of iron oxide nanoparticles (FeONPs) using micro-emulsion-hydrothermal method. By adjusting the synthesis temperature, we successfully produced FeO nanorods and nanospheres. In addition, the 2-octanol, and the surfactant cetyltrimethylammonium bromide served as a solvent in the synthesis process.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!