5,2'-Dibromo-2,4,5-trihydroxydiphenylmethanone, a novel immunomodulator of T lymphocytes by regulating the CD4 T cell subset balance via activating the mitogen-activated protein kinase pathway.

Int Immunopharmacol

School of Pharmaceutical Science, Shanxi Medical University, Taiyuan, Shanxi 030001, PR China; Shanxi Key Laboratory of Chronic Inflammatory Targeted Drugs, School of Traditional Chinese Materia Medical, Shanxi University of Chinese Medicine, Taiyuan 030619, PR China. Electronic address:

Published: July 2019

5,2'-Dibromo-2,4',5'-trihydroxydiphenylmethanone (LM49) exerted therapeutic effects against rat acute pyelonephritis by regulating immune responses, especially affecting T lymphocytes. However, its underlying action mechanism remains unclear. T lymphocytes play an irreplaceable role in immune responses. Therefore, we sought to understand whether LM49 is an immunomodulator of T lymphocytes. The results showed that LM49 promoted T lymphocyte proliferation, increased the number of CD4 T cells, and increased the CD4/CD8 T cell ratio. LM49 regulated the CD4 T cell subset balance by increasing the production of CD4IL-2, CD4IL-4, and CD4IL-10, and reducing the production of CD4IL-17, without changing the production of interferon-γ. LM49 had a significant effect on the mRNA expression of the transcription factors T-bet, GATA3, Foxp3, and RORγt. Furthermore, LM49 raised the phospho (p)-extracellular signal-regulated protein kinase 1/2, p-p38, and p-c-Jun N-terminal kinase expression levels. T cell proliferation, and the production of CD4IL-2, CD4IL-4, and CD4IL-10 induced by LM49, were decreased by inhibitors of mitogen-activated protein kinases (MAPKs). These results revealed that LM49 possesses immunomodulatory activity on T lymphocytes, in which the MAPK pathway plays an essential role.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.04.034DOI Listing

Publication Analysis

Top Keywords

immunomodulator lymphocytes
8
cd4 cell
8
cell subset
8
subset balance
8
mitogen-activated protein
8
protein kinase
8
lm49
8
immune responses
8
production cd4il-2
8
cd4il-2 cd4il-4
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!