Magnetic resonance imaging is excellent at characterizing pediatric hepatobiliary pathology. Noncontrast MRI is helpful due to T2 hyperintensity associated with bile, but contrast enhancement offers additional means of lesional characterization. In particular, hepatocyte-specific contrast agents such as gadoxetate disodium (Eovist) exhibit partial hepatobiliary excretion which may be leveraged in these contexts. In this review, we will discuss gadoxetate disodium usage, including a sample-imaging protocol, and demonstrate applications and limitations in the pediatric population.
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http://dx.doi.org/10.1067/j.cpradiol.2019.04.001 | DOI Listing |
Hepatol Commun
January 2025
Department of Pathology, Keio University School of Medicine, Tokyo, Japan.
Background: Vessels encapsulating tumor clusters (VETC) pattern is tumor vasculature of HCC and is a predictor of prognosis and therapeutic efficacy. Recent radiological studies have demonstrated the predictability of VETC from preoperative images, but the mechanisms of image formation are not elucidated. This study aims to determine the relationship between VETC and intratumor heterogeneity in Gd-EOB-DTPA-enhanced magnetic resonance imaging (EOB-MRI) and to provide its pathological evidence.
View Article and Find Full Text PDFEur Radiol
December 2024
7T Magnetic Resonance Translational Medicine Research Center, Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Objective: To develop a novel hybrid model for preoperative prediction of tertiary lymphoid structures (TLSs) of hepatocellular carcinoma (HCC), and to identify patients who may benefit from postoperative targeted immunotherapy.
Methods: Retrospective data were gathered from 332 patients with HCC who underwent surgical resection and gadoxetate disodium (Gd-EOB-DTPA) enhanced MRI at two tertiary hospitals (training cohort, n = 205; internal validation cohort, n = 90; and external validation cohort, n = 37) between March 2020 and January 2023. Radiomic features were extracted from Gd-EOB-DTPA-enhanced MRI sequences.
Medicine (Baltimore)
December 2024
Department of Radiology, Dong-A University College of Medicine, Busan, Republic of Korea.
Since 2007, the combination of atezolizumab and bevacizumab, comprising an immune checkpoint inhibitor and a molecularly targeted agent, has become the first-line treatment for advanced hepatocellular carcinoma (HCC). Predicting prognosis prior to systemic chemotherapy remains a critical concern. This study included 84 advanced HCC patients who underwent enhanced computed tomography (CT) and Gd-EOB-DTPA magnetic resonance imaging (MRI) before the systemic therapy were included.
View Article and Find Full Text PDFZhonghua Gan Zang Bing Za Zhi
November 2024
Department of Pathology, the Third Affiliated Nantong Hospital of Nantong University, Nantong226000, China.
To analyze the hepatobiliary phase (HBP) image manifestation classification and pathological features of nodules in nodules accompanied by hepatocellular carcinoma (NIN-HCC). Twenty-five cases cases (27 lesions) with cirrhosis who were confirmed as NIN-HCC by surgical pathology and underwent gadoxetate disodium-enhanced MRI examination before surgery at Nantong Third Hospital affiliated with Nantong University from July 2015 to November 2022 were retrospectively enrolled. The size, signal intensity, enhancement pattern, and pathological features of internal and external nodules were analyzed in NIN-HCC.
View Article and Find Full Text PDFEur Radiol
November 2024
Department of Radiology, Zhongshan Hospital of Fudan University, Shanghai, China.
Objectives: To explore the value of T1 mapping-based whole-liver histogram analysis on gadoxetic acid-enhanced MRI for predicting post-hepatectomy liver failure (PHLF).
Methods: Consecutive patients from March 2016 to March 2018 who underwent gadoxetic acid-enhanced MRI in our hospital were retrospectively analyzed, and 37 patients were enrolled. Whole-liver T1 mapping-based histogram analysis was performed.
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