Purpose: To evaluate the usefulness of the video indirect ophthalmoscope (VIO) to improve resident ophthalmologist skill with indirect ophthalmoscopy (IO) and scleral depression (SD).
Design: Prospective, randomized, double-arm interventional study.
Participants: Ten ophthalmology residents were enrolled in an educational program using the Heine Video Omega 2C VIO (Heine USA Ltd, Dover, NH) and served as the study group. Ten other experience-matched ophthalmology residents functioned as the control group.
Methods: At baseline, all study and control residents completed surveys assessing their subjective comfort and skill with IO. Each resident also completed a standardized full IO examination with SD that was recorded using the VIO. Each resident in the study group received 3 monthly 1-hour teaching sessions using the VIO. Surveys and recorded standardized examinations were repeated for all residents after the 3-month period. Both baseline and final examination videos were graded using a standardized grading scale by 3 independent retina faculty members masked to the identities of the residents and timing of the examination.
Main Outcome Measures: Improved visualization of the peripheral retina (ora serrata) as evaluated by masked graders was the primary outcome measure. Improved examination efficiency grade was the secondary outcome measure.
Results: Both the study group and the control group had significant improvement in ability to examine the peripheral retina and ora serrata compared with baseline (P = 0.02 and P = 0.03, respectively). The study group also showed significantly improved examination efficiency compared with baseline, which was not noted in the control group (P = 0.01 and P = 0.53, respectively). The study group self-reported significantly improved confidence in the ability to identify retinal tears, whereas the control group did not (P = 0.003 and P = 0.08, respectively). Study group participants also reported significantly improved ability to recognize retinal holes (P = 0.003), subretinal fluid (P = 0.02), and vitreoretinal tufts (P = 0.02), whereas the control group did not.
Conclusions: This novel educational study suggests that VIO as part of a structured teaching program may improve resident ophthalmologist confidence and ability with identifying retinal pathologic features using IO with SD.
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http://dx.doi.org/10.1016/j.oret.2016.12.010 | DOI Listing |
Sci Rep
January 2025
Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany.
Community-acquired pneumonia (CAP) has a significant impact on public health, especially in light of the recent SARS-CoV-2 pandemic. To enhance disease characterization and improve understanding of the underlying mechanisms, a comprehensive analysis of the plasma lipidome, metabolome and proteome was conducted in patients with viral and bacterial CAP infections, including those induced by SARS-CoV-2. Lipidomic, metabolomic and proteomic profiling were conducted on plasma samples of 69 patients suffering either from viral or bacterial CAP.
View Article and Find Full Text PDFBMJ Open
October 2024
Consellería de Sanidade e o Servizo Galego de Saúde, Santiago de Compostela, Spain.
Introduction: Linezolid is a broadly used antibiotic to treat complicated infections caused by gram-positive bacteria. Therapeutic drug monitoring of linezolid concentrations is recommended to maximise its efficacy and safety, mainly haematological toxicity. Different pharmacokinetic/pharmacodynamic targets have been proposed to improve linezolid exposure: the ratio of the area under the concentration-time curve during a 24-hour period to minimum inhibitory concentration (MIC) between 80 and 120; percentage of time that the drug concentration remains above the MIC during a dosing interval greater than 85% and the trough concentration between 2 and 7 mg/L.
View Article and Find Full Text PDFOur study investigates the post-mortem findings of the diaphragm's muscular structural changes in mechanically ventilated COVID-19 patients. Diaphragm samples of the right side from 42 COVID-19 critically ill patients were analyzed and correlated with the type and length of mechanical ventilation (MV), ventilatory parameters, prone positioning, and use of sedative drugs. The mean number of fibers was 550±626.
View Article and Find Full Text PDFHaematologica
August 2024
Miloš Mladenović, ;Charlotte Flasshove, Bojana Mišković, ;José-María Ribera-Santasusana, Martin Hoenigl, Juergen Prattes, Malgorzata Mikulska, Annarosa Cuccaro, Emel Bekirova, Josip Batinić, ;Nick De Jonge, Tatjana Adžić-Vukičević, ;Ľuboš Drgoňa, Hans Martin Orth, Florian Reizine, Monica Piedimonte, Jörg Schubert, Andrés Soto-Silva, Jorge Loureiro-Amigo, Laura Serrano, Lisset Lorenzo De La Peña, Anna Guidetti, Irati Ormazabal-Vélez, Sandra Malak, Maria Calbacho, Noemí Fernández, Rafael F. Duarte, Elizabeth De Kort, Guldane Cengiz Seval, Luisa Verga, Rui Bergantim, María-Josefa Jiménez-Lorenzo, Johan Maertens, Nina Khanna, Matthias Egger, Omar-Francisco Coronel-Ayala, Przemyslaw Zdziarski, Alessandro Busca, Elena Busch, Christian Bjørn Poulsen, François Danion, Tania Cushion, Sergio Pinzón, Yung Gonzaga, Austin Kulasekararaj, Hossein Zarrinfar, Baerbel Hoell-Neugebauer, Chi Shan Kho, Rémy Duléry, Martin Kolditz, Monica Fung, Alina Daniela Tanase.
Ann Intensive Care
March 2024
Department of Emergency and Critical Care Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan.
Background: In some cases of patients with out-of-hospital cardiac arrest (OHCA) who underwent extracorporeal cardiopulmonary resuscitation (ECPR), negative pupillary light reflex (PLR) and mydriasis upon hospital arrival serve as common early indicator of poor prognosis. However, in certain patients with poor prognoses inferred by pupil findings upon hospital arrival, pupillary findings improve before and after the establishment of ECPR. The association between these changes in pupillary findings and prognosis remains unclear.
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