Introduction: Magnetic resonance cholangiopancreatography (MRCP) has achieved widespread success as a diagnostic tool for hepatobiliary lesions. MRCP offers an effective method of hepatobiliary diagnosis that is safer than the use of invasive procedures, namely endoscopic retrograde cholangiopancreatography, and is more accurate than ultrasound.
Aim: The aim of the study was to assess the diagnostic quality and overall accuracy of MRCP for the evaluation of hepatobiliary lesions.
Patients And Methods: Eighty patients (42 male, 38 female; mean age, 38.3 years) suspected for hepatobiliary lesions were enrolled in this study. MRCP protocols applied for imaging of the hepatobiliary system were T2-weighted fast spin echo sequence on axial and coronal planes; three-dimensional, fat suppressed, heavily T2-weighted fast spin echo sequence with multislab acquisition mode; two-dimensional thick single slab projectional images, and three-dimensional reconstruction algorithms.
Results: Among the patients, jaundice and biliary colic were the commonest clinical complaints. MRCP has detected different pathologic entities among congenital anomalies, inflammatory conditions, neoplastic disorders, and postoperative and post-traumatic complications. The MRCP diagnosis was compared with the final diagnosis reached by endoscopic retrograde cholangiopancreatography, surgical, or histopathologic data. MRCP has a high overall diagnostic accuracy of 97%, sensitivity of 98%, and specificity of 93%.
Conclusions: MRCP provides a safe, noninvasive, accurate diagnostic tool in detection of the presence and level of biliary obstruction and also denotes its cause with high accuracy.
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http://dx.doi.org/10.1016/j.jmir.2015.09.006 | DOI Listing |
Cureus
February 2025
Gastroenterology and Hepatology, Baylor Scott & White All Saints Medical Center, Fort Worth, USA.
Intraductal papillary mucinous neoplasms (IPMNs) are a prevalent subtype of pancreatic cystic lesions, especially among individuals with liver cirrhosis. Intraductal papillary neoplasms of the bile duct (IPNBs) differ in histopathology based on the location and cellular variability in each location. Intrahepatic IPNBs are less aggressive than the extrahepatic variant, highlighting its heterogeneity and complexity.
View Article and Find Full Text PDFBMC Cancer
March 2025
Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka, 589-8511, Japan.
Background: Atezolizumab plus bevacizumab is recommended as a first-line treatment for unresectable hepatocellular carcinoma (uHCC). A subgroup analysis of the IMbrave150 trial showed shorter overall survival (OS) in uHCC patients with stable disease (SD) than patients with complete response (CR) or partial response (PR) after atezolizumab plus bevacizumab. Improving OS in patients with SD is an unmet medical need.
View Article and Find Full Text PDFCancer Cell
March 2025
Department of Biliary-Pancreatic Surgery, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China; Shanghai Key Laboratory of Systems Regulation and Clinical Translation for Cancer, Shanghai 200127, China; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Shanghai 200127, China. Electronic address:
Gallbladder cancer (GBC) frequently mimics gallbladder benign lesions (GBBLs) in radiological images, leading to preoperative misdiagnoses. To address this challenge, we initiated a prospective, multicenter clinical trial (ChicCTR2100049249) and proposed a multimodal, non-invasive diagnostic model to distinguish GBC from GBBLs. A total of 301 patients diagnosed with gallbladder-occupying lesions (GBOLs) from 11 medical centers across 7 provinces in China were enrolled and divided into a discovery cohort and an independent external validation cohort.
View Article and Find Full Text PDFWorld J Gastrointest Surg
February 2025
State Key Laboratory of Chemical Biology, Research Center of Chemical Kinomics, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
This article comments on the study by Peng , published in the , representing a notable advancement in hepatobiliary surgery. This article examines laparoscopic anatomical segment VIII resection, a challenging procedure due to the complex liver anatomy and difficulty in accessing deep-seated lesions. Peng and colleagues' experience with caudal and cranial approaches in 34 patients underscores the feasibility of these techniques while sparking debates about the optimal approach.
View Article and Find Full Text PDFLancet Reg Health Eur
April 2025
Department of Surgery, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy.
Background: An increasing number of liver resections are performed laparoscopically, while laparoscopic resection of lesions in the posterosuperior segments is technically challenging. We aimed to assess the outcomes of laparoscopic and open parenchymal preserving resection of lesions in the posterosuperior segments in a randomised controlled trial.
Methods: In this multicentre, patient-blinded, superiority randomised controlled trial, patients requiring parenchymal preserving liver resection for tumours in segment 4a, 7, or 8 were enrolled at 17 centres and randomised 1:1 to laparoscopic or open surgery using a minimisation scheme stratifying for centre and lesion size.
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