Background And Objective: The congestive heart failure (CHF) is a life-threatening cardiac disease which arises when the pumping action of the heart is less than that of the normal case. This paper proposes a novel approach to design a classifier-based system for the automated detection of CHF.
Methods: The approach is founded on the use of the Stockwell (S)-transform and frequency division to analyze the time-frequency sub-band matrices stemming from electrocardiogram (ECG) signals. Then, the entropy features are evaluated from the sub-band matrices of ECG. A hybrid classification scheme is adopted taking the sparse representation classifier and the average of the distances from the nearest neighbors into account for the detection of CHF. The proposition is validated using ECG signals from CHF subjects and normal sinus rhythm from public databases.
Results: The results reveal that the proposed system is successful for the detection of CHF with an accuracy, a sensitivity and a specificity values of 98.78%, 98.48%, and 99.09%, respectively. A comparison with the existing approaches for the detection of CHF is accomplished.
Conclusions: The time-frequency entropy features of the ECG signal in the frequency range from 11 Hz to 30 Hz have higher performance for the detection of CHF using a hybrid classifier. The approach can be used for the automated detection of CHF in tele-healthcare monitoring systems.
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http://dx.doi.org/10.1016/j.cmpb.2019.03.008 | DOI Listing |
Nan Fang Yi Ke Da Xue Xue Bao
January 2025
Department of Cardiology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing 210022, China.
Objectives: To analyze the differentially expressed exosomal miRNAs in patients with chronic heart failure (CHF) complicated by hyperuricemia (HUA) and explore their potential as novel diagnostic molecular markers and their target genes.
Methods: This study was conducted among 30 CHF patients with HUA (observation group) and 30 healthy volunteers (control group) enrolled between September, 2020 and September, 2023. Peripheral blood samples were collected from 6 CHF patients with HUA for analyzing exosomal miRNAs by high-throughput sequencing, and the results were validated in the remaining 24 patients using qRT-PCR.
J Cardiothorac Surg
January 2025
Department of Cardiology, The Affiliated Hospital of Xuzhou Medical University, No.99 West Huaihai Road, Quanshan District, Xuzhou, 221000, China.
Background: MicroRNAs (miRNAs) are closely related to cardiovascular diseases, including chronic heart failure (CHF). Endothelial dysfunction can lead to heart failure. The purpose of this study was to evaluate the clinical significance of miR-1285-3p in CHF patients, with the aim of identifying a novel and effective biomarker for CHF.
View Article and Find Full Text PDFBiosens Bioelectron
March 2025
Department of Physical Chemistry, Institute of Chemistry, Faculty of Chemistry and Geosciences, Vilnius University (VU), Naugarduko St. 24, LT-03225, Vilnius, Lithuania; Department of Nanotechnology, State Research Institute Center for Physical and Technological Sciences (FTMC), Sauletekio Ave. 3, LT-10257, Vilnius, Lithuania. Electronic address:
Herein, we report the development and characterisation of an electrochemical biosensor with a polypyrrole (Ppy)-based molecularly imprinted polymer (MIP) for the serological detection of the recombinant nucleocapsid protein of SARS-CoV-2 (rN). The electrochemical biosensor utilises a Ppy-based MIP formed on a self-assembled monolayer (SAM) at the gold interface to enhance Ppy layer stability on the screen-printed electrode (SPE). Electrochemical impedance spectroscopy (EIS) and square wave voltammetry (SWV) were employed for the electrochemical characterisation of screen-printed gold electrodes (SPGEs) modified with MIP or non-imprinted polymer (NIP) layers.
View Article and Find Full Text PDFChest
December 2024
Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine.
Background: The management of incidental pulmonary nodules is guided by recommendations set forth by the Fleischner Society. While most pulmonary nodules are benign, timely and evidence-based follow-up can reduce morbidity and mortality. There are known socioeconomic disparities for engagement with recommended cancer screenings, however it is unclear whether disparities exist for follow-up of incidentally detected pulmonary lesions.
View Article and Find Full Text PDFCell Biochem Biophys
December 2024
Department of Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Glutathione (GSH) is a master antioxidant that counters oxidative stress. Clinical studies have confirmed significant depletion of GSH in the hippocampus and the substantia nigra as an early diagnostic biomarker for Alzheimer's disease (AD) and Parkinson disease (PD), respectively. External agents like anesthetics (inhaled and intravenous) have a different impact on GSH.
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