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Molecular and genetic characterization of carbapenemase-producing bacteria in Venezuela. | LitMetric
Carbapenem-resistant Gram-negative bacteria isolated in Venezuela have been poorly characterized. The present study characterized a total of 34 isolates obtained from 27 patients; five of these patients were multi-infected. The bacterial species identified were (17), (9), and (8). From these isolates, 85% were identified as carbapenemase-producing bacteria, and the identified carbapenemase genes were (10/29 [34.4%]), (7/29 [24.1%]), (7/29 [24.1%]), (8/29 [27.5%]), and the coexistence of / (2/29 [6.8%]). Patient 1 was multi-infected by ST11 and ST2413 isolates harbouring the and genes, respectively. The other patients were multi-infected by two or three different bacterial species such as ESBL-producing isolates, harbouring the gene, ST147 harbouring the gene and by harbouring the gene. The gene in is flanked by an uncommon genetic structure, whereas gene in revealed a common structure described in different plasmids from isolates. This study provides new information about the epidemiology of carbapenemase-producing bacteria in clinical setting in Venezuela.
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