AI Article Synopsis
- The study investigates how different types of antigens (TD, TI-1, and TI-2) affect the responses of B cell populations, specifically looking at the variation in antibody specificity among daughter cells from parent PFC (plaque-forming cells) after stimulation with TD and TI antigens.
- Findings show that PFC responsive to TD antigens produced daughter cells with diverse antibody specificities, while PFC responding to TI antigens largely maintained the original parental specificity.
- The results suggest distinct behaviors and possibly different subpopulations of B cells are involved in responses to TD versus TI antigens, indicating that the nature of the antigen influences B cell differentiation and specificity.
Article Abstract
The classification of antigens into TD, TI-1 and TI-2 varieties raises the question of whether responses to these antigens are produced by distinct or identical subpopulations of B cells. In the present study we have examined the extent of intraclonal specificity variation in the progeny of PFC appearing after stimulation with two unrelated antigens. Mouse lymphoid cells were stimulated with pairs of TD and TI antigens, PFC were individually cultured and daughter PFC examined for their specificity. In all combinations used, PFC responding to TD antigen engendered, after 48 h of culture, a high frequency of PFC daughters expressing one or the other antibody specificity, notwithstanding the specificity of parental PFC. However, PFC responding to TI antigens seemed less subject to variation in specificity, and PFC daughters engendered after a 48 h culture period were, in the majority, of the parental specificity. These results are analysed in relation to different subpopulations of B cells.
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| http://dx.doi.org/10.1111/j.1744-313x.1986.tb01120.x | DOI Listing |
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