Background: We present the case of a 6-y-old boy who was diagnosed with sensory processing disorder with developmental language and learning delay. He was treated successfully with diet and high-dose biotin along with other nutrient support that resulted in resolution of abnormal sensory behaviors and improvement in language and learning.
Case/intervention: The child was diagnosed with a presumed biotin deficiency from organic acids testing which revealed markers that reflected biotin deficiency despite supplementation with 300 mcg daily (AI = 12 mcg/d). Stool markers were also noted for low beneficial biotin producing microbiota. In the course of several months of high-dose biotin supplementation with herbal treatment for dysbiosis, he was able to subsequently transition from special needs classes requiring sensory support into mainstream classes as a neurotypical child with age appropriate language and learning skills and resolution of abnormal sensory behaviors.
Conclusion: This case illustrates the importance of using functional nutrition labs to rule out nutrient imbalances that could be a cause of improper signaling in the brain, which can translate into delayed language, learning, and behavior disorders. Organic acids may reveal a much higher level of need of nutrients, especially when polymorphisms of enzymes are present that may be responsive, as this case demonstrates, to targeted high-dose nutrient therapy.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469460 | PMC |
Mol Neurobiol
January 2025
Department of Nutrition, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey.
Demyelination is commonly observed in neurodegenerative disorders, including multiple sclerosis (MS). Biotin supplementation is known to stabilize MS progression. To reduce the effective dose of biotin, we synthesized a new and superior form of biotin, a complex of magnesium ionically bound to biotin (MgB) and compared its dose-dependent effect with biotin alone after inducing demyelination using lysolecithin (LPC) in rats.
View Article and Find Full Text PDFNutrients
June 2024
Department of Food Technology, Tekirdag Namik Kemal University, 59030 Tekirdag, Türkiye.
The hawthorn fruit is an interesting medicinal plant that has several biological features, especially related to anti-inflammatory, antioxidant and immune-modulating actions, and boosting general health. In this study, we aimed to clarify the immunological effects of hawthorn vinegar on immunity and general health. We also focused on three different production processes to improve the antioxidant activity of hawthorn vinegar (2) Methods: In the study, besides the traditional production of hawthorn vinegar (N), thermal pasteurization (P) and ultrasound (U) techniques were applied to vinegars.
View Article and Find Full Text PDFPeerJ
April 2024
Department of Respiratory Medicine, Huzhou Central Hospital, Huzhou, Zhejiang Province, China.
Background: Acute pulmonary embolism (APE) is classified as a subset of diseases that are characterized by lung obstruction due to various types of emboli. Current clinical APE treatment using anticoagulants is frequently accompanied by high risk of bleeding complications. Recombinant hirudin (R-hirudin) has been found to have antithrombotic properties.
View Article and Find Full Text PDFJ Epilepsy Res
December 2023
Department of Radiology, Al Taif Children Hospital, Al Taif, Saudi Arabia.
Biotin-thiamine-responsive basal ganglia disease (BTBGD) is a rare, inherited neurometabolic disorder caused by mutations in the gene and characterized by recurrent sub-acute episodes of encephalopathy that are often triggered by infections. Patients with BTBGD have classical neuroimaging findings and a dramatic response to high doses of thiamine. Herein, we report a 2 and a half-year-old Saudi girl presented with an acute onset of ataxia, slurred speech, and dysphagia, which was preceded by a history of accidental ingestion of around 20 mL of ethyl alcohol that is used in formulating perfumes 1 day earlier.
View Article and Find Full Text PDFBMC Neurol
October 2023
AP-HP, Hôpital Henri Mondor, CRC SEP Grand Paris Est, 94010, Créteil, France.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!