AI Article Synopsis
- The study examines factors influencing neurologic deterioration in patients with spontaneous cerebellar hemorrhage (SCH) during hospitalization, emphasizing the importance of identifying these factors for better clinical decision-making.
- Out of 155 patients studied over 10 years, 17.4% experienced neurologic deterioration, with significant predictors including obliteration of the basal cistern, hydrocephalus, median Glasgow Coma Scale score, and intracerebral hemorrhage (ICH) score at admission.
- Key findings reveal that patients with basal cistern obliteration on initial CT scans have a nearly 9-fold increased risk of deterioration, and a higher ICH score correlates with an 83.2% increase in deterioration
Article Abstract
Background: Cerebellar hemorrhage is a potentially life-threatening condition and neurologic deterioration during hospitalization could lead to severe disability and poor outcome. Finds out the factors influencing neurologic deterioration during hospitalization is essential for clinical decision-making.
Methods: One hundred fifty-five consecutive patients who suffered a first spontaneous cerebellar hemorrhage (SCH) were evaluated in this 10-year retrospective study. This study aimed to identify potential clinical, radiological and clinical scales risk factors for neurologic deterioration during hospitalization and outcome at discharge.
Results: Neurologic deterioration during hospitalization developed in 17.4% (27/155) of the patient cohort. Obliteration of basal cistern (p≦0.001) and hydrocephalus (p≦0.001) on initial brain computed tomography (CT), median Glasgow Coma Scale (GCS) score at presentation (p≦0.001) and median intracerebral hemorrhage (ICH) score (P≦0.001) on admission were significant factors associated with neurologic deterioration. Stepwise logistic regression analysis showed that patients with obliteration of basal cistern on initial brain CT scan had an odds ratio (OR) of 9.17 (p = 0.002; 95% confidence interval (CI): 0.026 to 0.455) adjusted risk of neurologic deterioration compared with those without obliteration of basal cistern. An increase of 1 point in the ICH score on admission would increase the neurologic deterioration rate by 83.2% (p = 0.010; 95% CI: 1.153 to 2.912). The ROC curves showed that the AUC for ICH score on presentation was 0.719 (p = 0.000; 95% CI: 0.613-0.826) and the cutoff value was 2.5 (sensitivity 80.5% and specificity 73.7%).
Conclusion: Patients had obliteration of basal cistern on initial brain CT and ICH score greater or equal to 3 at admission implies a greater danger of neurologic deterioration during hospitalization. Cautious clinical assessments and repeated brain images study are mandatory for those high-risk patients to prevent neurologic deterioration during hospitalization.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6495504 | PMC |
| http://dx.doi.org/10.1186/s12883-019-1312-8 | DOI Listing |
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