We investigate the route to self-excited thermoacoustic instability in a laminar flow multiple flame matrix burner. With an increase in the equivalence ratio, the thermoacoustic system that is initially quiet (stable operation) transitions to limit cycle oscillations through two distinct dynamical states, namely, bursting oscillations and mixed mode oscillations. The acoustic pressure oscillations transition from quiescence to large amplitudes during bursting oscillations. Such high amplitude bursting oscillations that occur well ahead of the onset of limit cycle oscillations can potentially cause structural damage. The thermoacoustic system exhibits hysteresis. The transition to limit cycle oscillations is replicated in a phenomenological model containing slow-fast time scales.
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http://dx.doi.org/10.1063/1.5095401 | DOI Listing |
Viruses
December 2024
Department of Microbiology, Virology, and Immunology, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, Ukraine.
Metformin, a widely used antidiabetic medication, has emerged as a promising broad-spectrum antiviral agent due to its ability to modulate cellular pathways essential for viral replication. By activating AMPK, metformin depletes cellular energy reserves that viruses rely on, effectively limiting the replication of pathogens such as influenza, HIV, SARS-CoV-2, HBV, and HCV. Its role in inhibiting the mTOR pathway, crucial for viral protein synthesis and reactivation, is particularly significant in managing infections caused by HIV, CMV, and EBV.
View Article and Find Full Text PDFViruses
November 2024
Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
The hepatitis C virus (HCV) infection, a global health concern, can lead to chronic liver disease. The HCV core antigen (HCVcAg), a viral protein essential for replication, offers a cost-effective alternative to HCV RNA testing, particularly in resource-limited settings. This review explores the significance of HCVcAg, a key protein in the hepatitis C virus, examining its structure, function, and role in the viral life cycle.
View Article and Find Full Text PDFSensors (Basel)
December 2024
Department of Semiconductor Systems Engineering, Sejong University, Seoul 05006, Republic of Korea.
Recently, AI systems such as autonomous driving and smart homes have become integral to daily life. Intelligent multi-sensors, once limited to single data types, now process complex text and image data, demanding faster and more accurate processing. While integrating NPUs and sensors has improved processing speed and accuracy, challenges like low resource utilization and long memory latency remain.
View Article and Find Full Text PDFSensors (Basel)
December 2024
Division de Fotónica, Centro de Investigaciones en Óptica AC, Loma del Bosque 115, Col. Lomas del Campestre, León 37150, Guanajuato, Mexico.
Methylene blue is a cationic organic dye commonly found in wastewater, groundwater, and surface water due to industrial discharge into the environment. This emerging pollutant is notably persistent and can pose risks to both human health and the environment. In this study, we developed a Surface Plasmon Resonance Biosensor employing a BK7 prism coated with 3 nm chromium and 50 nm of gold in the Kretschmann configuration, specifically for the detection of methylene blue.
View Article and Find Full Text PDFPharmaceutics
December 2024
Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, China.
Background: The clinical efficacies of anticancer drugs are limited by non-selective toxic effects on healthy tissues and low bioavailability in tumor tissue. Therefore, the development of vehicles that can selectively deliver and release drugs at the tumor site is critical for further improvements in patient survival.
Methods: We prepared a CEC nano-drug delivery system, CEC@ZIF-8, with a zeolite imidazole framework-8 (ZIF-8) as a carrier, which can achieve the response of folate receptor (FR).
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