With the deep understanding of the time-varying characteristics of real systems, research studies focusing on the temporal network spring up like mushrooms. Community detection is an accompanying and meaningful problem in the temporal network, but the analysis of this problem is still in its developing stage. In this paper, we proposed a temporal spectral clustering method to detect the invariable communities in the temporal network. Through integrating Fiedler's eigenvectors of normalized Laplacian matrices within a limited time window, our method can avoid the inaccurate partition caused by the mutation of the temporal network. Experiments demonstrated that our model is effective in solving this problem and performs obviously better than the compared methods. The results illustrated that taking the historical information of the network structure into consideration is beneficial in clustering the temporal network.
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J Autism Dev Disord
December 2024
School of Information Science and Engineering, Yanshan University, Qinhuangdao, 066004, China.
Autism spectrum disorder (ASD) has been reported to exhibit altered local functional consistency. However, previous studies mainly focused on male samples and explored the temporal consistency in the ASD brain ignoring the spatial consistency. In this study, FOur-dimensional Consistency of local neural Activities (FOCA) analysis was used to investigate the sex differences of local spatiotemporal consistency of spontaneous brain activity in ASD.
View Article and Find Full Text PDFJ Exp Clin Cancer Res
December 2024
Scientific Direction, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
On September 23-24 (2024) the 6th Workshop IRE on Translational Oncology, titled "Cancer Organoids as Reliable Disease Models to Drive Clinical Development of Novel Therapies," took place at the IRCCS Regina Elena Cancer Institute in Rome. This prominent international conference focused on tumor organoids, bringing together leading experts from around the world.A central challenge in precision oncology is modeling the dynamic tumor ecosystem, which encompasses numerous elements that evolve spatially and temporally.
View Article and Find Full Text PDFCommun Biol
December 2024
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Epithelial-to-mesenchymal transition (EMT) is a conserved cellular process critical for embryogenesis, wound healing, and cancer metastasis. During EMT, cells undergo large-scale metabolic reprogramming that supports multiple functional phenotypes including migration, invasion, survival, chemo-resistance and stemness. However, the extent of metabolic network rewiring during EMT is unclear.
View Article and Find Full Text PDFSci Rep
December 2024
Henan University of Engineering, Zhengzhou, 451191, China.
Social media generates vast amounts of spatio-temporal sequential data. However, current methods often ignore the complex spatio-temporal correlations within these data. This oversight makes it difficult to fully capture the dynamic features of the data.
View Article and Find Full Text PDFNat Aging
December 2024
Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago de Chile, Chile.
Structural inequality, the uneven distribution of resources and opportunities, influences health outcomes. However, the biological embedding of structural inequality in aging and dementia, especially among underrepresented populations, is unclear. We examined the association between structural inequality (country-level and state-level Gini indices) and brain volume and connectivity in 2,135 healthy controls, and individuals with Alzheimer's disease and frontotemporal lobe degeneration from Latin America and the United States.
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