Efficacy of simultaneous VEGF-A/ANG-2 neutralization in suppressing spontaneous choroidal neovascularization.

EMBO Mol Med

Ophthalmology Discovery, Pharma Research& Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.

Published: May 2019

This study independently confirms in the JR5558 mouse model of aberrant retinal angiogenesis, that simultaneous VEGF‐A and ANG‐2 neutralization using a bispecific anti‐VEGF‐A/ANG‐2 antibody reduces vascular leakage, immune reactivity and apoptosis more effectively than either agent alone.[Image: see text]

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505683PMC
http://dx.doi.org/10.15252/emmm.201810204DOI Listing

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