Tamoxifen restores extracellular trap formation in neutrophils from patients with chronic granulomatous disease in a reactive oxygen species-independent manner.

Atul Sharma Katelyn McCann Jitendra Kumar Tripathi Pooja Chauhan Christa Zerbe Bibhuti B Mishra Steven M Holland Jyotika Sharma

J Allergy Clin Immunol

Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND. Electronic address:

Published: August 2019

Tamoxifen induces autophagy-dependent NET formation in CGD patient neutrophils and improves their antimicrobial activity. Given the genetic defect in their ROS-generation machinery, this study highlights repurposing of tamoxifen to potentiate host defense in CGD patients.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688929	PMC
http://dx.doi.org/10.1016/j.jaci.2019.04.014	DOI Listing

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