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Background The National Kidney Foundation (NKF) and the American Society of Nephrology (ASN) developed new race-free eGFR equations and recommended using these new equations in 2021. However, clinical implication of these new equations is not determined in Korean adults. Thus, this study aimed to evaluate performances of these new race-free eGFR equations in predicting complications in Korean chronic kidney disease (CKD) patients.
View Article and Find Full Text PDFPredictive Value of Serum Hepcidin Levels for the Risk of Incident End-Stage Kidney Disease in Patients with Chronic Kidney Disease: The KNOW-CKD.
Kidney Dis (Basel)
December 2024
Department of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju, Republic of Korea.
Introduction: Despite the pivotal role of hepcidin in the development of anemia among the patients with chronic kidney disease (CKD), the association between serum hepcidin levels and CKD progression has been never investigated. We here hypothesized that elevation in serum hepcidin levels might be associated with the risk of incident end-stage kidney disease (ESKD) among the patients with pre-dialysis CKD.
Methods: A total of 2,109 patients with pre-dialysis CKD at stages 1 to pre-dialysis 5 were categorized into the quartiles by serum hepcidin levels.
Circulating osteoprotegerin and progression of coronary artery calcification in patients with chronic kidney disease: the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD).
Kidney Res Clin Pract
November 2024
Department of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea.
Background: Coronary artery calcification (CAC) is a surrogate of cardiovascular events in patients with chronic kidney disease (CKD). To establish the role of circulating osteoprotegerin (OPG) as a cardiovascular biomarker in patients with CKD, we investigated whether an increase in serum OPG levels is associated with the risk of CAC progression.
Methods: A total of 1,130 patients with CKD stage 1 to predialysis 5 were divided into quartiles according to serum OPG levels (Q1 to Q4).
Smoking cessation and atherosclerotic cardiovascular events and mortality in chronic kidney disease.
Nephrol Dial Transplant
November 2024
Department of Internal Medicine, College of Medicine, Institute of Kidney Disease Research, Yonsei University, Seoul, Korea.
Article Synopsis
- Smoking cessation is crucial for reducing cardiovascular disease and mortality in patients with chronic kidney disease (CKD), but most guidelines are based on general population studies, not specifically CKD patients.
- An analysis of over 66,000 CKD participants found that both former and current smokers had significantly higher risks of atherosclerotic cardiovascular disease (ASCVD) and mortality, with risk increasing based on smoking history and decreasing with longer cessation periods.
- Former smokers with CKD need longer cessation periods (at least 20 years) to diminish risks to levels comparable to never smokers, highlighting the necessity for targeted smoking cessation strategies in this population.
Patient-reported mental health problems and clinical outcomes in adults with non-dialysis chronic kidney disease.
Kidney Res Clin Pract
October 2024
Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
Background: Mental health affects well-being and physical health. Among adults with chronic kidney disease (CKD), mental health (MH) problems are common and can induce adverse clinical outcomes. We examined the association between patient-reported MH problems and clinical outcomes in adults with non-dialysis CKD.
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