AI Article Synopsis
- Eugenia dysenterica, a Brazilian tree, contains bioactive compounds like tannins and flavonoids that may offer therapeutic benefits, although its effects on oral tissues have not been previously studied.
- This study assessed the cytotoxic, antioxidant, and repair properties of its acetone fraction using human gingival fibroblasts and murine macrophage cells, revealing a cytoprotective effect and potential antioxidant properties, but no anti-inflammatory activity was observed.
- The findings suggest that Eugenia dysenterica could be beneficial when combined with chlorhexidine for oral health, but further research is needed on different parts of the plant and other oral tissues to explore its potential as a mouthwash for oral disorders.
Article Abstract
Eugenia dysenterica is a Brazilian tree investigated for its properties and bioactive compounds, which are believed to have both pharmacological and phytochemical therapeutic effects. The leaves of this tree contain tannins, flavonoids, terpenes, and saponins, with reportedly beneficial effects to the human body. Despite these therapeutic applications, its effects have never been tested on oral tissues. Therefore, the aim of the present study was to evaluate the cytotoxic and antioxidant effects and the anti-inflammatory and repair properties of the acetone fraction of E. dysenterica on primary culture of human gingival fibroblasts and on the immortalized murine macrophage cell line (RAW 264.7). For this purpose, a metabolic activity assay, a wound healing assay, a nitric oxide assay, and RT-qPCR were performed. The assays revealed a cytoprotective effect of this plant, suggested by the increase in the expression of SOD1 and NRF2. An antioxidant potential effect was observed in the DPPH• assay. However, the fraction of E. dysenterica did not show anti-inflammatory activity. In conclusion, Eugenia dysenterica may promote cytoprotection when associated with chlorhexidine digluconate because of its antioxidant effect. However, additional studies are necessary on other human dental tissues using other parts of the plant in order to develop a possible mouthwash to assist patients with oral disorders.
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| http://dx.doi.org/10.1590/1807-3107bor-2019.vol33.0035 | DOI Listing |
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