In this case report, an 83-year-old woman with dementia was admitted to hospital with vomiting and diarrhoea. Her medical history included dementia, atrial fibrillation and seizures. She had accidentally ingested a kind of "fruit", which was used as part of a flower decoration in her room. When admitted, she was in hypovolaemic shock and hypoxic. The ingested "fruit" was identified as squirting cucumber: Ecballium elaterium, which is known to cause vomiting and diarrhoea, according to the Danish poison centre. The patient's condition deteriorated despite intravenously given fluid and antibiotic treatment for a suspected aspiration pneumonia. She died two hours after admission.
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Ann Intern Med
January 2025
Centre of Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital; Division of Experimental Medicine, McGill University; Department of Epidemiology, Biostatistics and Occupational Health, McGill University; Department of Medicine, McGill University; and Division of Cardiology, Jewish General Hospital/McGill University, Montreal, Quebec, Canada (M.J.E.).
Background: Recent randomized controlled trials (RCTs) have investigated glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual or triple co-agonists for weight loss among adults with overweight or obesity and without diabetes.
Purpose: To assess the efficacy and safety of GLP-1 RAs and co-agonists for the treatment of obesity among adults without diabetes.
Data Sources: MEDLINE, Embase, and Cochrane CENTRAL from inception to 4 October 2024.
Cureus
December 2024
Subir Chowdhury School of Quality and Reliability, Indian Institute of Technology, Kharagpur, IND.
This article comprehensively reviews the working, efficacy, and safety profile of zolbetuximab. Zolbetuximab is a pioneering chimeric monoclonal antibody designed to target Claudin 18.2 (CLDN18.
View Article and Find Full Text PDFTher Adv Drug Saf
January 2025
College of Pharmacy, Jinan University, Guangzhou, Guangdong 511436, China.
Background: Clarithromycin is a widely used antibiotic, but its safety profile, particularly in different age groups, remains inadequately explored.
Objectives: This study aims to characterize and illustrate the features of clarithromycin-related adverse events (AEs) across different age groups using the FDA Adverse Event Reporting System (FAERS) database, providing a reference for the clinical detection, prevention, and management of AEs in various age groups.
Design: A disproportionality analysis was performed using data from the FAERS database.
Mol Nutr Food Res
January 2025
Department of Veterinary Surgery, College of Animal Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, China.
Cisplatin (CIS) is a broad-spectrum anticancer drug widely used in the clinic; however, one of its side effects is that it can cause intestinal damage such as loss of appetite, vomiting, and diarrhea in patients. Epigallocatechin gallate (EGCG) is one of the main active substances in green tea, which has the effects of antitumor multiple drug resistance, antioxidation, and antiinflammatory properties. The aim of this study was to explore the protective effect of EGCG on CIS-induced intestinal injury in rats.
View Article and Find Full Text PDFBalkan Med J
January 2025
Department of Gastrointestinal Surgery, Changzhou Maternal and Child Health Care Hospital, Changzhou, China.
Background: Postoperative nutritional support in gastrointestinal cancer, including enteral nutrition (EN), parenteral nutrition (PN), and combined nutrition strategies, is vital for enhancing recovery and patient outcomes.
Aims: We aimed to comprehensively evaluate the impact of postoperative EN, PN, and EN + PN in patients with gastrointestinal cancer.
Methods: PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wan Fang, and VIP were searched from conception until January 2, 2024.
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