As part of our continual efforts to exploit 'Tujia Ethnomedicine' for their pharmacophoric functionalities, we herein investigated collected from a deep Wulin mountain area in northern Hunan province. The current study resulted in the isolation of three new sesquiterpenes: 6α,9α,15-trihydroxycadinan-4-en-3-one (), (+)-3,11,12-trihydroxycalamenene (), (-)-3,10,11,12-tetrahydroxy-calamenene (), along with four known sesquiterpenes (-), and a cytochalasin H (). Their chemical structures were elucidated by 1D-, and 2D-NMR spectroscopy, and HRESI-MS, CD spectrometry. The antioxidant, and cytotoxic activities of the compounds were evaluated. Compound exhibited a strong antioxidant effect with an IC value of 3.67 µM on isolated human polymorphonuclear cells or neutrophils.
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| http://dx.doi.org/10.3390/molecules24091664 | DOI Listing |
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