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Ultrasound-assisted efficient targeting of doxorubicin to the tumor microenvironment by lyso-thermosensitive liposomes of varying phase transition temperatures.
Eur J Pharm Sci
January 2025
Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:
Premature drug release is the primary hindrance to the effective function of the lyso-thermosensitive liposomes (LTSLs) of doxorubicin (Dox), known as ThermoDox® for the treatment of cancer. Herein, we have optimized LTSLs by using a combination of phospholipids (PLs) with high transition temperatures (Tm) to improve the therapeutic outcome in an assisted ultrasound approach. For this, several Dox LTSLs were prepared using the remote loading method at varying molar ratios (0 to 90%) of DPPC (Tm 41°C) and HSPC (Tm 54.
View Article and Find Full Text PDFInsight into selective removal of trace thallium (Tl(Ι)) by novel chitosan adsorbents encapsulating low-cost silicate mineral wastes.
Environ Res
January 2025
Nanjing Institute of Environmental Sciences, Ministry of Ecology and Environment (MEE), Nanjing, 210042, PR China.
Recently, thallium (Tl) contamination at trace levels has gained worldwide attention, particularly in the remote ore-smelting regions of China. To effectively eliminate the residual target Tl(I) ions, one of the best strategies is to develop novel adsorbents with high selectivity. In this study, we selected silicate mineral waste (SMW) and chitosan (CTS) to synthesize a low-cost composite adsorbent for the removal of trace Tl(I).
View Article and Find Full Text PDFImproving Wellness Through Reading Room Design and Flexible Scheduling Options.
J Breast Imaging
January 2025
Department of Radiology, The University of Alabama at Birmingham, Birmingham, AL, USA.
Breast radiologists have high rates of burnout. Some contributing factors include the sedentary nature of the occupation, reading room design and isolation associated with higher volumes, and increased remote interpretation. Reading rooms can also be filled with numerous distractions and produce conditions that do not support optimal workflow.
View Article and Find Full Text PDFOptimization of Video Heart Rate Detection Based on Improved SSA Algorithm.
Sensors (Basel)
January 2025
School of Sciences, Xi'an Technological University, Xi'an 710021, China.
A solution to address the issues of environmental light interference in Remote Photoplethysmography (rPPG) methods is proposed in this paper. First, signals from the face's region of interest (ROI) and background noise signals are simultaneously collected, and the two signals are processed by a differential to obtain a more accurate rPPG signal. This method effectively suppresses background noise and enhances signal quality.
View Article and Find Full Text PDFA Review of CNN Applications in Smart Agriculture Using Multimodal Data.
Sensors (Basel)
January 2025
Institut de Recherche en Informatique de Toulouse, IRIT UMR5505 CNRS, 31400 Toulouse, France.
This review explores the applications of Convolutional Neural Networks (CNNs) in smart agriculture, highlighting recent advancements across various applications including weed detection, disease detection, crop classification, water management, and yield prediction. Based on a comprehensive analysis of more than 115 recent studies, coupled with a bibliometric study of the broader literature, this paper contextualizes the use of CNNs within Agriculture 5.0, where technological integration optimizes agricultural efficiency.
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