Mono- or bidentate boron Lewis acids trigger a regioselective magnesiation or zincation of pyridazine in position C3 (ortho product) or C4 (meta product). The regioselectivity of the metalation was rationalized with the help of calculated pK values of both pyridazine and pyridazine/Lewis acid complexes.
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| http://dx.doi.org/10.1002/anie.201903839 | DOI Listing |
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