AI Article Synopsis
- Early diagnosis of tumor cells is crucial for effective cancer treatment, and the slightly acidic tumor environment can be used to identify these cells through pH measurement.
- A new SERS nanoprobe, made from gold nanoflowers and a pH-responsive reporter, successfully maps pH levels in cells, providing accurate measurements.
- This innovative probe allows for distinguishing between normal and tumor cells, offering a promising imaging tool for early cancer diagnosis.
Article Abstract
Objectives: Early diagnosis of tumour cells is critically important for cancer treatment. Given that the tumour environment is slightly acidic, the pH value of the cell environment can be used as a criterion for tumour diagnosis. However, mapping pH in the cell environment with high resolution, high sensitivity and accuracy remains challenging.
Materials And Methods: Based on gold nanoflower as surface-enhanced Raman scattering (SERS) substrate loading with p-mercaptobenzoic acid (MPA) as pH-responsive Raman reporter, a new SERS nanoprobe for pH mapping was developed.
Results: This probe showed a characteristic Raman spectrum signal in response to the different pH in solutions or cells. The signal intensity is positively correlated to the pH value. Moreover, this probe is self-correctable, which can help eliminate the influence of probe concentration on the accuracy of pH measuring.
Conclusions: We demonstrate the pH mapping of cell environment using the probe, which can be used to distinguish normal cells and tumour cells. This method may provide a new imaging tool for early diagnosis of cancer.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669020 | PMC |
| http://dx.doi.org/10.1111/cpr.12618 | DOI Listing |
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