Two young patients with a-v conduction disturbances occurring in relation with strenuous physical effort are presented. The possible mechanism may be an excessive vagal tone.
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Alzheimers Dement
December 2024
Applied Medical Sciences, Misr University for Science and Technology, Cairo, Egypt.
Background: Gamma desynchronization is an early pathophysiological event in Alzheimer's disease with a disturbance in oscillation in the gamma frequency range 30-80 Hz. This disruption was found to be directly related to the disease progression and severity. Thus, the use of transcranial alternating current stimulation (tACS) possessed greater interest.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Soleo Health, Frisco, TX, USA.
Background: The approval of anti-amyloid monoclonal antibodies (mAbs) provides a novel approach to the treatment of Alzheimer's disease. Infusions in alternative sites of care can benefit the patient financially and logistically, but coverage is largely payor dependent. The purpose of this study is to describe observations from this national complex specialty pharmacy around the safety of anti-amyloid mAb infusions in alternative sites of care, including the home.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
NYU Aging Incubator, New York, NY, USA.
Background: Most persons living with dementia (PLWD) experience sleep disturbances at some point during their disease. Music interventions are promising to address sleep disturbances because long-term memory for music remains relatively preserved in PLWD. The purpose of this study was to identify the prototype features of the mobile application, entitled, "Calming Music Personalized for Sleep Enhancement in PeRsons living with Dementia" (CoMPoSER) for use among PLWD and their caregivers by conducting the first round of qualitative interviews to co-design the content, features, and layout of the application prototype.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Johns Hopkins University School of Medicine, Baltimore, MD, USA.
The presentation of neuropsychiatric and sleep features in Lewy body dementia (LBD) are challenging to identify and manage. The US Based Diamond Lewy Neuropsychiatric Symptoms management guidelines provide expert consensus recommendations for the assessment and treatment of the neuropsychiatric features of LBD. These guidelines address the management of delusions, hallucinations, agitation and aggression, apathy, depression and anxiety.
View Article and Find Full Text PDFBackground: Behavioural and psychological symptoms (BPSD) are common in major cognitive disorders and an important driver of suffering and high care needs. The Swedish BPSD registry was founded in 2010 to develop an evidence base for quality improvement in the care of patients with BPSD. Here we describe the process of establishing and operating the registry, the patient population included, and data collected since the start of the registry in 2010.
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