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FeMOFs/CO loading reduces NETosis and macrophage inflammatory response in PLA based cardiovascular stent materials.
Regen Biomater
December 2024
Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan 610031, China.
Modification of polylactic acid (PLA) is a promising strategy for the next generation of bioresorbable vascular stent biomaterials. With this focus, FeMOFs nanoparticles was incorporated in PLA, and then post loading of carbon monoxide (CO) was performed by pressurization. It showed FeMOFs incorporation increased hydrophilicity of the surface and CO loading, and CO release was sustained at least for 3 days.
View Article and Find Full Text PDFRecent Advances in Polyurethane for Artificial Vascular Application.
Polymers (Basel)
December 2024
College of Materials Science and Engineering, Wuhan Textile University, Wuhan 430070, China.
Artificial blood vessels made from polyurethane (PU) have been researched for many years but are not yet in clinical use. The main reason was that the PU materials are prone to degradation after contact with blood and will also cause inflammation after long-term implantation. At present, PU has made progress in biostability and biocompatibility, respectively.
View Article and Find Full Text PDFA Review of Additive Manufacturing of Biodegradable Fe and Zn Alloys for Medical Implants Using Laser Powder Bed Fusion (LPBF).
Materials (Basel)
December 2024
Department of Applied Mathematics, Materials Science and Engineering and Electronic Technology, Escuela Superior de Ciencias Experimentales y Tecnología (ESCET), Universidad Rey Juan Carlos, C/Tulipán s/n, 28933 Móstoles, Spain.
This review explores the advancements in additive manufacturing (AM) of biodegradable iron (Fe) and zinc (Zn) alloys, focusing on their potential for medical implants, particularly in vascular and bone applications. Fe alloys are noted for their superior mechanical properties and biocompatibility but exhibit a slow corrosion rate, limiting their biodegradability. Strategies such as alloying with manganese (Mn) and optimizing microstructure via laser powder bed fusion (LPBF) have been employed to increase Fe's corrosion rate and mechanical performance.
View Article and Find Full Text PDFEnhancing percutaneous coronary intervention using TriVOCTNet: a multi-task deep learning model for comprehensive intravascular optical coherence tomography analysis.
Phys Eng Sci Med
January 2025
Faculty of Engineering, Department of Biomedical Engineering, Universiti Malaya, Kuala Lumpur, Malaysia.
Article Synopsis
- Neointimal coverage and stent apposition are critical for improving percutaneous coronary interventions (PCI), but current algorithms struggle with automating the analysis of diverse stent types and preselecting necessary segments.
- This study introduces TriVOCTNet, a multi-task deep learning model designed to automate the classification, lumen segmentation, and stent strut segmentation in IVOCT images, all within one efficient network.
- TriVOCTNet demonstrated impressive accuracy with high classification rates and precise segmentation outputs, indicating its potential for enhancing clinical practices in PCI procedures.
Effects of structural design on the mechanical performances of poly-L-lactic acid cardiovascular scaffolds using FEA and in vitro methods.
J Mech Behav Biomed Mater
December 2024
Department of Bionanosystem Engineering, Graduate School, Jeonbuk National University, Jeonju 54896, Republic of Korea; Department of Bionanotechnology and Bioconvergence Engineering, Graduate School, Jeonbuk National University, Jeonju 54896, Republic of Korea; Department of Mechanical Design Engineering, Graduate School, Jeonbuk National University, Jeonju 54896, Republic of Korea; Advanced Mechanical Components Design & Research Center, Jeonbuk National University, Jeonju 54896, Republic of Korea; Innovative Mechanobio Active Materials Based Medical Device Demonstration Center, Jeonbuk National University, Jeonju 54896, Republic of Korea. Electronic address:
Article Synopsis
- This study aimed to explore new scaffold geometries for improving the mechanical performance of Poly-L-lactic Acid (PLLA) bioresorbable vascular scaffolds (BVS) using finite element analysis (FEA) and lab experiments.
- Four different scaffold designs were subjected to simulations and tests, focusing on various mechanical properties like crush resistance and radial strength.
- The results revealed that Design B outperformed others in key performance metrics, suggesting new PLLA scaffold geometries could enhance their use in cardiovascular applications.
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