AI Article Synopsis
- Rotavirus causes 39% of diarrheal deaths in children under five globally, with India accounting for 22% of these fatalities; the introduction of the Rotavac vaccine in 2016 aims to combat this issue.
- An active surveillance system has been implemented to track acute gastroenteritis cases in children under five, collecting data and stool samples from vaccinated individuals to assess the vaccine's effectiveness.
- The study has received ethical approval from relevant boards and will share findings through peer-reviewed journals and with stakeholders in India's universal immunization program.
Article Abstract
Introduction: Rotavirus infection accounts for 39% of under-five diarrhoeal deaths globally and 22% of these deaths occur in India. Introduction of rotavirus vaccine in a national immunisation programme is considered to be the most effective intervention in preventing severe rotavirus disease. In 2016, India introduced an indigenous rotavirus vaccine (Rotavac) into the Universal Immunisation Programme in a phased manner. This paper describes the protocol for surveillance to monitor the performance of rotavirus vaccine following its introduction into the routine childhood immunisation programme.
Methods: An active surveillance system was established to identify acute gastroenteritis cases among children less than 5 years of age. For all children enrolled at sentinel sites, case reporting forms are completed and a copy of vaccination record and a stool specimen obtained. The forms and specimens are sent to the referral laboratory for data entry, analysis, testing and storage. Data from sentinel sites in states that have introduced rotavirus vaccine into their routine immunisation schedule will be used to determine rotavirus vaccine impact and effectiveness.
Ethics And Dissemination: The Institutional Review Board of Christian Medical College, Vellore, and all the site institutional ethics committees approved the project. Results will be disseminated in peer-reviewed journals and with stakeholders of the universal immunisation programme in India.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502045 | PMC |
| http://dx.doi.org/10.1136/bmjopen-2018-024840 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background: Diarrhoeal diseases claim more than 1 million lives annually and are a leading cause of death in children younger than 5 years. Comprehensive global estimates of the diarrhoeal disease burden for specific age groups of children younger than 5 years are scarce, and the burden in children older than 5 years and in adults is also understudied. We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 to assess the burden of, and trends in, diarrhoeal diseases overall and attributable to 13 pathogens, as well as the contributions of associated risk factors, in children and adults in 204 countries and territories from 1990 to 2021.
View Article and Find Full Text PDFBiotechnological Interventions for the Production of Subunit Vaccines Against Group A Rotavirus.
Cell Biochem Funct
December 2024
Department of OS & OT, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Group A rotavirus (RVA) is a major cause of severe gastroenteritis in infants and young children globally, despite the availability of live-attenuated vaccines. Challenges such as limited efficacy in low-income regions, safety concerns for immunocompromised individuals, and cold-chain dependency necessitate alternative vaccine strategies. Subunit vaccines, which use specific viral proteins to elicit immunity, provide a safer and more adaptable approach.
View Article and Find Full Text PDFPrioritizing vaccine introduction to China's National Immunization Program: a multi-criteria decision analysis.
BMC Public Health
December 2024
National Institute of Hospital Administration, National Health Commission, Beijing, 100080, China.
Background: To prioritize the introducing of new vaccines into China's National Immunization Program (NIP) among 10 candidate vaccines across four classes.
Methods: We developed a vaccine value framework using Multi-Criteria Decision Analysis (MCDA) to simulate the introduction of new vaccines into NIP, covering 21 criteria encompassing six dimensions: safety, effectiveness, economy, innovation, accessibility, and appropriateness. Two decision scenarios were considered: Scenario One prioritized the four classes of vaccines, while Scenario Two identified specific vaccines within each class.
Development of RT-dPCR method and reference material for rotavirus G3P8 and G9P8.
Anal Bioanal Chem
December 2024
Center for Advanced Measurement Science, National Institute of Metrology, Beijing, 100029, China.
The rotavirus (RV) is the predominant causative pathogen associated with acute gastroenteritis in children aged below 5 years, leading to an annual mortality rate of 200,000 infants globally. Despite the development of a vaccine, it exacerbates the medical burden around the world. Here, we have developed reverse transcription digital PCR (RT-dPCR) methods for precise and absolute quantification of nucleic acid in rotavirus G3P8 and G9P8.
View Article and Find Full Text PDFCorrigendum to "Development and validation of a VP7-specific EIA for determining the potency and stability of inactivated rotavirus vaccine" [J. Virol. Method 332 (2025) 115079].
J Virol Methods
December 2024
Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address:
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!