To achieve sensitive plasmonic biosensors, it is essential to develop an efficient method for concentrating analytes in hot spots, as well as to develop plasmonic nanostructures for concentrating light. In this study, target analytes were delivered to the surface of double-bent Au strip arrays by a multiple dip-coating method; they were self-aligned in the valleys between neighboring Au strips by capillary forces. As the valleys not only accommodate target analytes but also host strong electromagnetic fields due to the interaction between adjacent strips, sensitive measurement of target analytes was possible by monitoring changes in the wavelength of a localized surface plasmon resonance. Using the proposed plasmonic sensor and target delivery method, the adsorption and saturation of polystyrene beads 100 nm in size on the sensor surface were monitored by the shift of the resonance wavelength. In addition, the pH-dependent stability of exosomes accumulated on the sensor surface was successfully monitored by changing the pH from 7.4 to 4.0.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567194 | PMC |
| http://dx.doi.org/10.3390/nano9050660 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Age-threshold for increased risk of developing back disorders: prospective cohort with 74 000 individuals from the UK Biobank.
Eur Spine J
January 2025
Exercise Intervention for Health Research Group (EXINH-RG), Department of Physiotherapy, University of Valencia, Valencia, Spain.
Objective: To investigate the prospective associations between age and the risk of low back disorders (LBD), dorsal disorders (DD), and cervical disorders (CD), and to identify a potential age-threshold for increased risk of back disorders.
Methods: Prospective cohort from the UK Biobank comprising adults with no history of back disorders. We examined different ages and their association with the risk of back disorders derived from diagnoses of hospital registers.
A Multimarker Approach to Identify Microbial Bioindicators for Coral Reef Health Monitoring-Case Study in La Réunion Island.
Microb Ecol
January 2025
IRD, UMR ENTROPIE, 15 Avenue René Cassin, CS 92003, 97744, Saint Denis Cedex 9, La Réunion, France.
The marine microbiome arouses an increasing interest, aimed at better understanding coral reef biodiversity, coral resilience, and identifying bioindicators of ecosystem health. The present study is a microbiome mining of three environmentally contrasted sites along the Hermitage fringing reef of La Réunion Island (Western Indian Ocean). This mining aims to identify bioindicators of reef health to assist managers in preserving the fringing reefs of La Réunion.
View Article and Find Full Text PDFStromal architecture and fibroblast subpopulations with opposing effects on outcomes in hepatocellular carcinoma.
Cell Discov
January 2025
Department of Liver Surgery and Transplantation, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.
Dissecting the spatial heterogeneity of cancer-associated fibroblasts (CAFs) is vital for understanding tumor biology and therapeutic design. By combining pathological image analysis with spatial proteomics, we revealed two stromal archetypes in hepatocellular carcinoma (HCC) with different biological functions and extracellular matrix compositions. Using paired single-cell RNA and epigenomic sequencing with Stereo-seq, we revealed two fibroblast subsets CAF-FAP and CAF-C7, whose spatial enrichment strongly correlated with the two stromal archetypes and opposing patient prognosis.
View Article and Find Full Text PDFBoric acid-substituted phthalocyanine/ciprofloxacin co-assembled nanoparticles for constructing bacteria-responsive intelligent wound dressings with synergistic therapy and recognition of bacterial infections.
Int J Biol Macromol
January 2025
Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China; Department of Rehabilitation Medicine, Affiliated Qingdao Central Hospital of Qingdao University, Qingdao Cancer Hospital, Qingdao, Shandong 266000, China. Electronic address:
In contemporary times, the waning effectiveness of antibiotics against bacterial infections is progressively giving rise to significant concerns in public health. Although photodynamic technology possesses a potent ability to deactivate bacteria, its non-selective attack on normal cells poses potential side effects. Hence, in this study, a boric acid-substituted phthalocyanine photosensitizer (BAPc) was synthesized, exhibiting remarkable bacterial targeting capability.
View Article and Find Full Text PDFBiomineralized and metallized small extracellular vesicles encapsulated in hydrogels for mitochondrial-targeted synergistic tumor therapy.
Acta Biomater
January 2025
Research Center for Analytical Sciences, Northeastern University, Shenyang, 110819, P. R. China. Electronic address:
Targeted organelle therapy is a promising therapeutic method for significantly regulating the tumor microenvironment, yet it often lacks effective strategies for leveraging synergistic enhancement effect. Engineered small extracellular vesicles (sEVs) are expected to address this challenge due to their notable advantages in drug delivery, extended circulation time, and intercellular information transmission. Herein, we prepare sEVs with pH and photothermal dual-responsiveness, which are encapsulated with hydrogels for a quadruple-efficient synergistic therapy.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!