Adjuvant haploidentical virus-specific T lymphocytes for treatment of disseminated adenovirus infection in a premature infant.

Jeffery J Auletta Pablo J Sánchez Erin K Meyer Lynn C O'Donnell Kevin A Cassady Christopher P Ouellette Shaina Hecht Alejandro Diaz Leeann R Pavlek Douglas P Salamon Christina L Gallagher Hillary Bradbury Sarah L Welfley Jacqueline Magers Debra L Armbruster Margaret G Lamb Robin J Nakkula Kevin Bosse Dean A Lee

J Allergy Clin Immunol

Hematology/Oncology/BMT, Nationwide Children's Hospital, Columbus, Ohio; Center for Childhood Cancer and Blood Diseases, Nationwide Children's Hospital, Columbus, Ohio; Department of Pediatrics, Department of Internal Medicine, Ohio State University College of Medicine, Columbus, Ohio; Ohio State University Comprehensive Cancer Center, Columbus, Ohio.

Published: August 2019

We report the first therapeutic infusion of haploidentical virus-specific T lymphocytes (VSTs) to treat maternally-transmitted, disseminated adenovirus infection in a premature infant. Infusion of maternal VSTs, isolated using interferon-gamma capture, associated with clinical improvement and viral clearance.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688973	PMC
http://dx.doi.org/10.1016/j.jaci.2019.04.006	DOI Listing

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