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Skeletal Muscle Relaxants and Their Impact on Intracranial Pressure in Neurosurgery.
Med Sci Monit
January 2025
Department of Rheumatology, University Clinical Hospital No. 1 Szczecin, Szczecin, Poland.
Skeletal muscle relaxants have their place in everyday use in numerous anesthesiological procedures, such as preparing a patient for surgery, supporting mechanical ventilation, and performing effective intubation. These drugs can be divided, based on their mechanism of action, into depolarizing skeletal relaxants, such as succinylcholine, and non-depolarizing skeletal muscle relaxants. Non-depolarizing agents are further categorized, based on their structure, into steroidal (eg, rocuronium) and benzylisoquinoline (eg, atracurium) compounds.
View Article and Find Full Text PDFLeft Ventricular Thrombosis in Immune Checkpoint Inhibitor Myocarditis Mimicking ST-Segment Elevation Myocardial Infarction.
JACC Case Rep
November 2024
Cardiology Unit, Morgagni Pierantoni Hospital Forlì, Italy.
Article Synopsis
- A case of ventricular thrombosis linked to myocarditis from immune checkpoint inhibitors (ICIs) presented as a myocardial infarction and worsened by severe cardiogenic shock.
- The rare occurrence of intraventricular thrombus formation in ICI-related myocarditis complicates diagnosis, particularly when distinguishing it from tumor masses in cancer patients.
- Effective diagnosis requires thorough clinical assessment and advanced imaging techniques, as cardiovascular complications from ICIs, though infrequent, can have high mortality rates.
Objective: We aim to provide a pictorial representation of the broad spectrum of intracranial hemorrhages associated with cerebral venous thrombosis (CVT), emphasizing atypical locations and rare intracerebral hemorrhage (ICH) types. We also hypothesize the pathophysiology leading to atypical locations of the ICH in CVT and the outcomes with anticoagulation therapy.
Background: ICH complicates about 40% of cases with CVT and is known to cause various types of ICH, including subarachnoid hemorrhage (SAH) and subdural hemorrhage (SDH).
Early detection of cerebral sinus venous thrombosis in an extremely low birth weight infant using cranial ultrasound-case report and literature review.
Childs Nerv Syst
November 2024
Neonatal Intensive Care Unit, IRCCS Giannina Gaslini Institute, 16147, Genoa, Italy.
Article Synopsis
- Cerebral sinus venous thrombosis (CSVT) is a serious condition in premature infants that can lead to complications like intraventricular hemorrhage if not diagnosed early.
- A case study demonstrated that serial cranial ultrasounds can effectively detect CSVT early, allowing for timely intervention.
- The use of anticoagulant therapy led to successful clot resolution, highlighting cranial ultrasound's importance as a diagnostic tool when MRI isn't available.
Coagulation assay results at birth in preterm infants: A cohort study highlighting the relevance of local reference values for interpretation.
Vox Sang
November 2024
Division of Neonatology, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, the Netherlands.
Background And Objectives: Routine coagulation screens at birth are still standard in some European neonatal intensive care units (NICUs), although interpretation of these results is complex in preterm infants. It is unclear to what extent local coagulation assay results agree with published reference ranges when using different analysers and reagents. We aimed to assess coagulation assay results on day 1 of life in very preterm infants admitted to the NICU.
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