Dizygotic twin pregnancies with discordant manifestation of abnormalities with unclear etiology are of interest because they arise in the same environment. We present a dizygotic third trimester twin placenta with discordant villous maturation, one placenta lacking developed syncytiocapillary membranes. The twins were eutrophic with no perinatal or postnatal complications. Discordant manifestation of villous maturation in dizygotic twin placentas could be a hint for a genetic rather than an environmental etiology. Villous maturation defect may be underrecognized and has been associated with perinatal morbidity and stillbirth in the late third trimester. Proper recognition is important because of the increased recurrence risk of villous dysmaturity.

Download full-text PDF

Source
http://dx.doi.org/10.1080/15513815.2019.1604924DOI Listing

Publication Analysis

Top Keywords

villous maturation
16
dizygotic twin
12
maturation defect
8
twin placenta
8
discordant manifestation
8
third trimester
8
discordancy villous
4
maturation
4
dizygotic
4
defect dizygotic
4

Similar Publications

Article Synopsis
  • Preeclampsia (PE) is a pregnancy-related disorder caused by issues with the placenta, making it challenging for clinicians to accurately diagnose due to a lack of standard diagnostic criteria.
  • This study explored the use of computational pathology to differentiate between PE and normal placentas by analyzing 168 placental images from two hospitals, employing both unsupervised and supervised learning techniques.
  • The resulting prediction model demonstrated good performance, achieving a sensitivity of 77.3% and specificity of 71.1%, indicating its potential effectiveness for identifying PE placentas in clinical settings.
View Article and Find Full Text PDF

Context.—: Assessment of placental villous maturation is among the most common tasks in perinatal pathology. However, the significance of abnormalities in morphology is unclear and interobserver variability is significant.

View Article and Find Full Text PDF

Characterising delayed villous maturation: A narrative literature review.

Placenta

December 2024

Maternal and Fetal Health Research Centre, Division of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK; Department of Obstetrics, Manchester University NHS Foundation Trust, Manchester, UK.

Article Synopsis
  • The placenta's normal development is really important for a baby to grow healthy during pregnancy, but there's a problem called Delayed Villous Maturation (DVM) that can cause stillbirths.
  • DVM happens when small structures in the placenta don't develop properly and are fewer in number, which can be linked to conditions like diabetes in mothers, but sometimes it just happens for no clear reason.
  • Doctors can only find out if DVM is present after the baby is born by looking at tissues under a microscope, and this review talks about ways to better recognize DVM so that it can be distinguished from healthy placentas.
View Article and Find Full Text PDF

Objective: In this study, it was aimed to investigate Urotensin II in intrauterine growth restriction (IUGR) and its connection to autophagy and/or apoptosis in placenta and umbilical cord by immunohistochemical and biochemical methods.

Materials And Methods: The study included 30 healthy pregnant women and 30 pregnant women with IUGR, aged 19-45, at Atatürk University Gynecology Clinic. Samples were collected from placenta, umbilical cord, maternal blood, and umbilical cord blood during delivery.

View Article and Find Full Text PDF

Objectives: Endometriosis is one of the leading causes of infertility, due to negative impact on ovarian folliculogenesis and endometrial receptivity. Literature show that endometriosis could be associated with perinatal complications such as preterm birth (PTB) and preeclampsia (PE). Authors hypothesized that women with endometriosis-related infertility conceived by assisted reproductive technology (ART) treatment have higher frequency of placental disorders.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!