AI Article Synopsis
- A case report details a Brazilian woman in her fifties who was hospitalized for schistosomiasis and found to be colonized by polymyxin-resistant E. coli and K. pneumoniae.
- Advanced methods, including antimicrobial susceptibility testing and whole genome sequencing, confirmed the presence of the mcr-1 gene in both bacteria strains identified as E. coli ST744 and K. pneumoniae ST101.
- The study highlights the emergence of mcr-1-harboring E. coli ST744, which is notably different from previously documented strains in Brazil, underlining the importance of monitoring antibiotic resistance.
Article Abstract
Case Presentation: We present a case report of a woman, concurrently colonized by polymyxin-resistant E. coli and K. pneumoniae. A Brazilian female patient, in her mid-fifties, was hospitalized with schistosomiasis. During hospitalization, polymyxin-resistant E. coli and K. pneumoniae were isolated from surveillance cultures.
Methods: Identification, antimicrobial susceptibility testings, PCR for mcr-1, plasmid transfer by conjugation and whole genome sequencing were performed.
Results: E. coli ST744 and K. pneumoniae ST101 carrying mcr-1 gene were described. Transconjugant E. coli was positive for mcr-1 and IncX4 by PCR. The plasmid is a 33,304-base pair plasmid, and the mcr-1 gene was the only antimicrobial resistance gene present in the plasmid.
Conclusions: This study presents a case report of a hospitalized woman, concurrently colonized by mcr-1-harboring E. coli ST744, a different ST from previously described in Brazil, and a K. pneumoniae ST101.
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| http://dx.doi.org/10.1007/s15010-019-01309-2 | DOI Listing |
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