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Ultrasound and x-ray imageable poloxamer-based hydrogel for loco-regional therapy delivery in the liver.
Sci Rep
September 2024
Center for Interventional Oncology, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Article Synopsis
- * A new thermosensitive poloxamer-based gel that can be imaged with x-ray and ultrasound was developed, using microbubbles to enhance visibility.
- * This gel aids in precise drug delivery by allowing for better imaging integration, potentially improving targeting and reducing radiation exposure during cancer treatments.
3D-printing inherently MRI-visible accessories in aiding MRI-guided biopsies.
3D Print Med
August 2024
Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden.
Background: 3D printers have gained prominence in rapid prototyping and viable in creating dimensionally accurate objects that are both safe within a Magnetic Resonance Imaging (MRI) environment and visible in MRI scans. A challenge when making MRI-visible objects using 3D printing is that hard plastics are invisible in standard MRI scans, while fluids are not. So typically, a hollow object will be printed and filled with a liquid that will be visible in MRI scans.
View Article and Find Full Text PDFUltrasound and x-ray imageable poloxamer-based hydrogel for loco-regional therapy delivery in the liver.
Res Sq
June 2024
Center for Interventional Oncology, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health.
Intratumoral injections have the potential for enhanced cancer treatment efficacy while reducing costs and systemic exposure. However, intratumoral drug injections can result in substantial off-target leakage and are invisible under standard imaging modalities like ultrasound (US) and x-ray. A thermosensitive poloxamer-based gel for drug delivery was developed that is visible using x-ray imaging (computed tomography (CT), cone beam CT, fluoroscopy), as well as using US by means of integrating perfluorobutane-filled microbubbles (MBs).
View Article and Find Full Text PDFAugmented Reality Guided Laparoscopic Liver Resection: A Phantom Study With Intraparenchymal Tumors.
J Surg Res
April 2024
Department of Digestive and Hepatobiliary Surgery, Hospital Estaing, CHU de Clermont-Ferrand, Clermont-Ferrand, France; UMR6602, Endoscopy and Computer Vision Group, Faculté de Médecine, Institut Pascal, Clermont-Ferrand, France. Electronic address:
Introduction: Augmented reality (AR) in laparoscopic liver resection (LLR) can improve intrahepatic navigation by creating a virtual liver transparency. Our team has recently developed Hepataug, an AR software that projects the invisible intrahepatic tumors onto the laparoscopic images and allows the surgeon to localize them precisely. However, the accuracy of registration according to the location and size of the tumors, as well as the influence of the projection axis, have never been measured.
View Article and Find Full Text PDFHandheld interventional ultrasound/photoacoustic puncture needle navigation based on deep learning segmentation.
Biomed Opt Express
November 2023
School of Biomedical Engineering, Shenzhen University, 1066 Xueyuan Ave, Shenzhen 518057, China.
Interventional ultrasound (US) has challenges in accurate localization of the puncture needle due to intrinsic acoustic interferences, which lead to blurred, indistinct, and even invisible needles in handheld linear array transducer-based US navigation, especially the incorrect needle tip positioning. Photoacoustic (PA) imaging can provide complementary image contrast, without additional data acquisition. Herein, we proposed an internal illumination to solely light up the needle tip in PA imaging.
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