Ginger has been widely used as a flavor, food, and traditional medicine for centuries. 6-Gingerol (6-Gin) is the active components of ginger and offers some beneficial effects on cardiovascular diseases. Here, the effects of 6-Gin on L-type Ca current (I), contractility, and the Ca transients of rat cardiomyocytes, were investigated via patch-clamp technique and the Ion Optix system. The 6-Gin decreased the I of normal and ischemic ventricular myocytes by 58.17 ± 1.05% and 55.22 ± 1.34%, respectively. 6-Gin decreased I in a concentration-dependent manner with a half-maximal inhibitory concentration (IC) of 31.25 μmol/L. At 300 μmol/L, 6-Gin reduced the cell shortening by 48.87 ± 5.44% and the transients by 42.5 ± 9.79%. The results indicate that the molecular mechanisms underlying the cardio-protective effects of 6-Gin may because of a decreasing of intracellular Ca via the inhibition of I and contractility in rat cardiomyocytes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475727 | PMC |
| http://dx.doi.org/10.1002/fsn3.968 | DOI Listing |
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