AI Article Synopsis
- Brain-derived neurotrophic factor (BDNF) plays a crucial role in the development of hippocampal circuits and cognition by influencing neuronal structure and synaptic plasticity.
- Recent research highlights that BDNF's effects are regulated through various mechanisms, including the transport and localization of its mRNA, the balance of BDNF release, and interactions with specific receptors.
- Disruptions in these mechanisms can lead to impaired formation of dendritic spines and affect the integration of new neurons into existing brain circuits, ultimately impacting cognitive function.
Article Abstract
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that has pleiotropic effects on neuronal morphology and synaptic plasticity that underlie hippocampal circuit development and cognition. Recent advances established that BDNF function is controlled and diversified by molecular and cellular mechanisms including trafficking and subcellular compartmentalization of different mRNA species, pre- vs. postsynaptic release of BDNF, control of BDNF signaling by tropomyosin receptor kinase B (TrkB) receptor interactors and conversion of pro-BDNF to mature BDNF and BDNF-propeptide. Defects in these regulatory mechanisms affect dendritic spine formation and morphology of pyramidal neurons as well as synaptic integration of newborn granule cells (GCs) into preexisting circuits of mature hippocampus, compromising the cognitive function. Here, we review recent findings describing novel dynamic mechanisms that diversify and locally control the function of BDNF in hippocampal neurons.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465932 | PMC |
| http://dx.doi.org/10.3389/fncel.2019.00135 | DOI Listing |
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