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Gadopiclenol: A q = 2 Gadolinium-Based MRI Contrast Agent Combining High Stability and Efficacy.
Invest Radiol
October 2024
From the Research and Innovation Department, Guerbet, Roissy, France (I.M., M.-C.D.G., J.-F.M., A.D., Y.B., N.D., I.S., G.B., C.M., C.F., O.R., S.C.); General, Organic, and Biomedical Chemistry Unit, NMR and Molecular Imaging Laboratory, University of Mons, Mons, Belgium (C.H., S.L.); and Institute of Inorganic and Analytical Chemistry, University of Münster, Münster, Germany (C.K., T.J.M., U.K.).
Objectives: Gadopiclenol is a q = 2 pyclen gadolinium-based contrast agent (GBCA) recently approved by the Food and Drug Administration, European Medicines Agency, and other European countries. The aim of this report is to demonstrate its stability in multiple stressed in vitro conditions and in vivo, in rat kidney, while maintaining its higher relaxivity compared with conventional GBCAs on the market.
Materials And Methods: Both gadopiclenol and its chemical precursor Pi828-Gd were characterized and compared with q = 1 gadolinium (Gd) complexes.
Electronic structure of metal oxide dications with ammonia ligands and their reactivity towards the selective conversion of methane to methanol.
Front Chem
December 2024
Department of Chemistry and Biochemistry, Auburn University, Auburn, AL, United States.
High-level quantum chemical calculations are performed for the (NH)MO and (NH)MO species (M = Ti-Cu), extending our previous work on the bare MO ions. The potential energy curves along the M-O distance are constructed for the ground and multiple excited electronic states of (NH)MO and are compared to those of MO. We see that ammonia stabilizes the oxo states (MO) over the oxyl (MO) ones.
View Article and Find Full Text PDFGreen-synthesized α-FeO-nanoparticles as potent antibacterial, anti-biofilm and anti-virulence agent against pathogenic bacteria.
BMC Microbiol
December 2024
Department of Physics, College of Science, University of Halabja, Halabja, Kurdistan Region, Iraq.
Background: Antimicrobial resistance (AMR) presents a serious threat to health, highlighting the urgent need for more effective antimicrobial agents with innovative mechanisms of action. Nanotechnology offers promising solutions by enabling the creation of nanoparticles (NPs) with antibacterial properties. This study aimed to explore the antibacterial, anti-biofilm, and anti-virulence effects of eco-friendly synthesized α-Fe₂O₃ nanoparticles (α-Fe₂O₃-NPs) against pathogenic bacteria.
View Article and Find Full Text PDFPhotocatalytic Multiple Deuteration of Polyethylene Glycol Derivatives using Deuterium Oxide.
Chemistry
December 2024
Osaka University, Graduate School of Pharmaceutical Sciences, 1-6, Yamada-oka, 565-0871, Osaka, JAPAN.
Deuterated molecules are of growing interest because of the specific characteristics of deuterium, such as stronger C-D bonds being stronger than C-H bonds. Polyethylene glycols (PEGs) are widely utilized in scientific fields (e.g.
View Article and Find Full Text PDFThree Dihydroquinolin-4-one Derivatives as Potential Biodiesel Additives: From the Molecular Structure to Machine Learning Approach.
ACS Omega
December 2024
Grupo de Química Teórica e Estrutural de Anápolis, Universidade Estadual de Goiás, 75132-903 Anápolis, GO, Brasil.
Biodiesel offers an alternative to fossil fuels, primarily because it is derived from renewable sources, with the potential to mitigate issues such as pollutant and greenhouse gas emissions, resource scarcity, and the market instability of petroleum derivatives. However, lower durability and stability pose challenges. To address this, researchers worldwide are exploring technologies that employ specific molecules to slow down biodiesel's oxidation process, thereby preserving its key physicochemical properties.
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