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AMPA Receptors in Synaptic Plasticity, Memory Function, and Brain Diseases.
Cell Mol Neurobiol
January 2025
Laboratory of Neurobiology, Centro de Investigaciones Medico Sanitarias (CIMES), University of Malaga, Calle Marqués de Beccaria, 3, Campus Teatinos s/n, 29010, Malaga, Spain.
Tetrameric AMPA-type ionotropic glutamate receptors are primary transducers of fast excitatory synaptic transmission in the central nervous system, and their properties and abundance at the synaptic surface are crucial determinants of synaptic efficacy in neuronal communication across the brain. The induction of long-term potentiation (LTP) leads to the insertion of GluA1-containing AMPA receptors at the synaptic surface, whereas during long-term depression (LTD), these receptors are internalized into the cytoplasm of the spine. Disruptions in the trafficking of AMPA receptors to and from the synaptic surface attenuate both forms of synaptic plasticity.
View Article and Find Full Text PDFAutomated Flow Synthesis of Artificial Heme Enzymes for Enantiodivergent Biocatalysis.
J Am Chem Soc
January 2025
Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
The remarkable efficiency with which enzymes catalyze small-molecule reactions has driven their widespread application in organic chemistry. Here, we employ automated fast-flow solid-phase synthesis to access catalytically active full-length enzymes without restrictions on the number and structure of noncanonical amino acids incorporated. We demonstrate the total syntheses of iron-dependent myoglobin (BsMb) and sperm whale myoglobin (SwMb).
View Article and Find Full Text PDFThe research progress and prospects of circadian rhythm in obesity: a bibliometric analysis.
Front Nutr
January 2025
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
Background: Numerous studies have shown a link between circadian rhythms disruptions and a higher risk of obesity. This article aims to conduct an extensive bibliometric analysis to deepen our understanding of the relationship between circadian rhythms and obesity.
Methods: The literature related to the circadian rhythm of obesity, published from the inception of the Web of Science Core Collection (WoSCC) until June 30, 2024, was extracted from the WoSCC databases (SCIE, SSCI, ESCI).
Study on the effects of Mogroside V in inhibiting NLRP3-mediated granulosa cell pyroptosis and insulin resistance to improve PCOS.
J Ovarian Res
January 2025
The First Affiliated Hospital, Gynecology&Obstetrics and Reproductive Medical Center, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.
Objective: Polycystic Ovary Syndrome (PCOS) is a prevalent endocrinopathy in reproductive-aged women, contributing to 75% of infertility cases due to ovulatory dysfunction. The condition poses significant health and psychological challenges, making the study of its pathogenesis and treatment a research priority. This study investigates the effects of Mogroside V (MV) on PCOS, focusing on its anti-inflammatory and anti-insulin resistance properties.
View Article and Find Full Text PDFDelayed post-juvenile moult in malaria-infected Eurasian blackcaps.
Proc Biol Sci
January 2025
Department of Biodiversity, Ecology and Evolution, Complutense University of Madrid, Madrid, Spain.
Parasites have their strongest impact on fitness when host defences deplete resources needed for other critical life-history stages, such as development, breeding or migration. Among birds, one greatly neglected stage that could be altered by parasites is post-juvenile moult (PJM), through which yearling juvenile birds replace their fast-generated, low-quality juvenile feathers with adult-like feathers after leaving the nest. The earlier the birds complete PJM, the earlier they will be prepared to withstand forthcoming challenges, such as adverse winter conditions or migration.
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