Aim: Fixed functional appliance (FFA) used in the treatment of Class II malocclusion, lead to mandibular anterior teeth proclination, thus limiting the skeletal effects of the appliance. To counter this side effect, FFA is anchored in the lower anterior region of the mandible using the skeletal anchorage system. This pilot study was done to evaluate treatment and one-year post-treatment maxillo-mandibular, and temporomandibular joint (TMJ) effects of conventional fixed functional appliance (FFA) and skeletal anchorage system supported fixed functional appliance (SAS-FFA) using cone beam computed tomography (CBCT) images.
Material And Method: Sixteen Class II individuals were equally divided into Group I (FFA) (mean age 13.11±0.38 years) and Group II (SAS-FFA) (mean age 12.96±0.38 years). CBCT scans taken, before treatment (T0), at the end of comprehensive treatment (T1), and after one-year post-treatment (T2), were evaluated for changes in maxillo-mandibular complex and TMJ. Intraclass correlation coefficient and independent "t" test were used for repeated measures, and inter-group (mean) changes respectively.
Results: After one-year post-comprehensive treatment, SAS-FFA showed significant maxillary restriction (SNA, -1.93°, P<0.05) with significant increase in mandibular length (Go-Pog, 3.25mm, P<0.001) (Co-Gn, 7.87mm, P<0.001). SAS-FFA groups showed significant upward and backward increase in condylar volume (571 mm, P<0.001) with anterior translation of glenoid fossa. FFA group showed significant lower dentition and vertical relationship relapse, along with non-significant changes at TMJ.
Conclusion: SAS-FFA is an effective combination, which brings favourable changes on maxillo-mandibular complex and temporomandibular joint with non-significant relapse in comparison to FFA at one-year post-treatment.
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http://dx.doi.org/10.1016/j.ortho.2019.03.008 | DOI Listing |
PNAS Nexus
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School of Physical Science and Engineering, Tongji University, Shanghai 200092, P. R. China.
Wiring patterns of brain networks embody a trade-off between information transmission, geometric constraints, and metabolic cost, all of which must be balanced to meet functional needs. Geometry and wiring economy are crucial in the development of brains, but their impact on artificial neural networks (ANNs) remains little understood. Here, we adopt a wiring cost-controlled training framework that simultaneously optimizes wiring efficiency and task performance during structural evolution of sparse ANNs whose nodes are located at arbitrary but fixed positions.
View Article and Find Full Text PDFAPMIS
January 2025
Department of Pathology, Herlev and Gentofte University Hospital, Herlev, Denmark.
The ovarian oncobiome is subject to increasing scientific focus, but a potential link between bacterial dysbiosis and ovarian carcinogenesis remains controversial. Our primary aim was to characterize the bacterial microbiota in epithelial ovarian cancer samples. Secondarily, we aimed to compare results from the bacterial microbiota in formalin-fixed, paraffin-embedded ovarian tissue samples from 194 patients with epithelial ovarian cancer, fallopian tube tissue samples from 16 patients with serous tubal intraepithelial carcinomas and in benign fallopian tube tissue samples from 25 patients.
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Department of Structural and Functional Biology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
Pituitary gland morphogenesis and the ontogeny of the adenohypophyseal (AH) cells of Astyanax lacustris are presented herein. This Characiformes species shows great ecological and commercial importance, and it has been increasingly used as animal model. For this study, A.
View Article and Find Full Text PDFJAMA Netw Open
January 2025
Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands.
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Med Sci Sports Exerc
January 2025
FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, GREECE.
Purpose: Exercise-induced heat acclimation can mitigate age-related reductions in heat-loss capacity, though performing repeated bouts of strenuous exercise in the heat may be untenable for many older adults. While short-term passive heat acclimation (e.g.
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