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MARCH8 Restricts RSV Replication by Promoting Cellular Apoptosis Through Ubiquitin-Mediated Proteolysis of Viral SH Protein.
Viruses
December 2024
Department of Virology 3, National Institute of Infectious Diseases, Musashimurayama 208-0011, Tokyo, Japan.
Numerous host factors function as intrinsic antiviral effectors to attenuate viral replication. MARCH8 is an E3 ubiquitin ligase that has been identified as a host restriction factor that inhibits the replication of various viruses. This study elucidated the mechanism by which MARCH8 restricts respiratory syncytial virus (RSV) replication through selective degradation of the viral small hydrophobic (SH) protein.
View Article and Find Full Text PDF4-1BBL-Armed Oncolytic Herpes Simplex Virus Exerts Antitumor Effects in Pancreatic Ductal Adenocarcinoma.
Vaccines (Basel)
November 2024
Beijing Institute of Biological Products Company Limited, Beijing 100176, China.
Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with a notably poor response to therapy due to its immunosuppressive tumor microenvironment (TME) and intrinsic drug resistance. The oncolytic virus (OV) represents a promising therapeutic strategy capable of transforming the "cold" immunological profile of PDAC tumors to a "hot" one by reshaping the TME. 4-1BB (CD137), a crucial member of the tumor necrosis factor receptor superfamily, plays a significant role in T-cell activation and function.
View Article and Find Full Text PDFEnhanced FFT-Root-MUSIC Algorithm Based on Signal Reconstruction via CEEMD-SVD for Joint Range and Velocity Estimation for FMCW Radar.
Sensors (Basel)
December 2024
Key Laboratory of Science and Technology on Micro-System, Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences, Shanghai 200050, China.
Frequency-modulated continuous-wave (FMCW) radar is used to extract range and velocity information from the beat signal. However, the traditional joint range-velocity estimation algorithms often experience significant performances degradation under low signal-to-noise ratio (SNR) conditions. To address this issue, this paper proposes a novel approach utilizing the complementary ensemble empirical mode decomposition (CEEMD) combined with singular value decomposition (SVD) to reconstruct the beat signal prior to applying the FFT-Root-MUSIC algorithm for joint range and velocity estimation.
View Article and Find Full Text PDFDetection and Quantification of DNA by Fluorophore-Induced Plasmonic Current: A Novel Sensing Approach.
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Department of Chemistry and Biochemistry, Institute of Fluorescence, University of Maryland, Baltimore County, 701 E Pratt St, Baltimore, MD 21202, USA.
We report on the detection and quantification of aqueous DNA by a fluorophore-induced plasmonic current (FIPC) sensing method. FIPC is a mechanism described by our group in the literature where a fluorophore in close proximity to a plasmonically active metal nanoparticle film (MNF) is able to couple with it, when in an excited state. This coupling produces enhanced fluorescent intensity from the fluorophore-MNF complex, and if conditions are met, a current is generated in the film that is intrinsically linked to the properties of the fluorophore in the complex.
View Article and Find Full Text PDFA Ray-Tracing-Based Single-Site Localization Method for Non-Line-of-Sight Environments.
Sensors (Basel)
December 2024
School of Physics, Xidian University, Xi'an 710071, China.
Localization accuracy in non-line-of-sight (NLOS) scenarios is often hindered by the complex nature of multipath propagation. Traditional approaches typically focus on NLOS node identification and error mitigation techniques. However, the intricacies of NLOS localization are intrinsically tied to propagation challenges.
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