Purpose Pictures consistently referred to by the same name (high agreement) are named faster than pictures that elicit inconsistent responses across individuals (low agreement). Although this effect is more pronounced in older adults apparently due to slower lexical selection, it is unclear whether this is consistent for different types of low agreement pictures. We investigated whether pictures with different sources of disagreement have differing selection requirements, as indexed by naming latencies. Method Picture naming latencies were compared for 20 young (ages 18-35 years) and 20 older adults (ages 60-80 years) across 3 object naming conditions: high name agreement, low name agreement due to multiple correct names, and low agreement due to abbreviations and elaborations. Results Compared to high agreement items, responses were slower specifically for low agreement items with multiple names, and to a lesser extent, items with abbreviations and elaborations ( p < .001). Older adults were slower than younger adults, especially for low agreement items with abbreviations and elaborations ( p = .031). Conclusions Our findings indicate differential lexical selection requirements for low agreement pictures, depending on the reason for agreement being low. This demonstrates the importance of differentiating the source of disagreement in any experimental or clinical assessment of picture naming.
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http://dx.doi.org/10.1044/2018_JSLHR-L-18-0095 | DOI Listing |
J Pathol Inform
January 2025
Cincinnati Children's AI Imaging Research (CAIIR) Center, Cincinnati, OH, United States.
Background: Traditional liver fibrosis staging via percutaneous biopsy suffers from sampling bias and variable inter-pathologist agreement, highlighting the need for more objective techniques. Deep learning models for disease staging from medical images have shown potential to decrease diagnostic variability, with recent weakly supervised learning strategies showing promising results even with limited manual annotation.
Purpose: To study the clustering-constrained attention multiple instance learning (CLAM) approach for staging liver fibrosis on trichrome whole slide images (WSIs) of children and young adults.
Cureus
December 2024
Reproductive Medicine, Torch Clinic, Tokyo, JPN.
Aim: This study compared the cost-effectiveness of two recombinant follicle-stimulating hormones (rFSH) formulations, Follitropin Delta and Follitropin Alfa, in controlled ovarian stimulation using cumulative live birth rates as an efficacy indicator.
Methodology: This retrospective study was conducted across five clinics in Japan from April 2022 to December 2023, involving 446 first assisted reproductive technology (ART) cycles (200 with Follitropin Delta and 246 with Follitropin Alfa) were treated with rFSH monotherapy using either Follitropin Delta or Follitropin Alfa. We compared clinical outcomes such as cumulative pregnancy and live birth rates and analyzed cost-effectiveness using the cumulative live birth rates as the efficacy indicator and the incremental cost-effectiveness ratio (ICER).
Int J Nephrol Renovasc Dis
January 2025
Astellas Pharma Singapore Pte. Ltd, Singapore, Singapore.
Introduction: Limited data exist regarding treatment patterns and symptom burden of patients with anemia of chronic kidney disease (CKD) in the Middle East, South Africa, and Türkiye.
Methods: This real-world study explored clinical characteristics, symptom burden, and treatment patterns of patients with anemia of CKD living in the Middle East, South Africa, and Türkiye. Physician and patient perceptions of treatment were captured via cross-sectional surveys; patients' clinical characteristics were recorded by retrospective review of medical records.
Adv Radiat Oncol
February 2025
Department of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Purpose: Ultrahypofractionation presents challenges for a subset of high-risk prostate cancer patients due to the large planning target volume (PTV) margin required for the seminal vesicles. Online adaptive radiation therapy could potentially reduce this margin. This paper focuses on the development, preclinical validation, and clinical testing of online adaptive robotic stereotactic body radiation therapy for this patient group.
View Article and Find Full Text PDFHeliyon
January 2025
Department of Oncology, The First Affiliated Hospital of Zhengzhou University, No.1 Eastern Jianshe Road, Zhengzhou, 450052, Henan, China.
Background: Cuproptosis is a unique form of cell death that is dependent on copper, which is fundamentally different from other recognized forms of cell death. However, the molecular and immune characteristics in cuproptosis-defined subgroups of cholangiocarcinoma (CCA) remain to be further illustrated.
Methods: We conducted a comprehensive investigation into the genetic and transcriptional variation, prognostic significance, and expression profiles of 16 cuproptosis-related genes (CRGs).
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