AI Article Synopsis
- Researchers have focused on highly toxic agents for effective targeted cancer therapy.
- A new method utilizing light has been developed to enhance the targeting of the drug 2-pyrrolinodoxorubicin.
- This strategy results in significant increases in toxicity and effectiveness, achieving single-digit nanomolar potency.
Article Abstract
Highly cytotoxic agents have found an important niche in targeted anticancer therapy. Here we develop a new light release strategy for the targeting of one of these agents, 2-pyrrolinodoxorubicin, showing dramatic enhancements in toxicity with light and single digit nM potency.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643956 | PMC |
| http://dx.doi.org/10.1039/c9cc02050k | DOI Listing |
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