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Integrated Local and Systemic Communication Factors Regulate Nascent Hematopoietic Progenitor Escape During Developmental Hematopoiesis.
Int J Mol Sci
December 2024
Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Mammalian blood cells originate from specialized 'hemogenic' endothelial (HE) cells in major arteries. During the endothelial-to-hematopoietic transition (EHT), nascent hematopoietic stem cells (HSCs) bud from the arterial endothelial wall and enter circulation, destined to colonize the fetal liver before ultimately migrating to the bone marrow. Mechanisms and processes that facilitate EHT and the release of nascent HSCs are incompletely understood, but may involve signaling from neighboring vascular endothelial cells, stromal support cells, circulating pre-formed hematopoietic cells, and/or systemic factors secreted by distal organs.
View Article and Find Full Text PDFExpression of Lumican and Osteopontin in Perivascular Areas of the Glioblastoma Peritumoral Niche and Its Value for Prognosis.
Int J Mol Sci
December 2024
Biochemistry, Molecular Biology B and Immunology Department, University of Murcia (UMU), 30120 Murcia, Spain.
Glioblastoma (GB) is one of the most aggressive and treatment-resistant cancers due to its complex tumor microenvironment (TME). We previously showed that GB progression is dependent on the aberrant induction of chaperone-mediated autophagy (CMA) in pericytes (PCs), which promotes TME immunosuppression through the PC secretome. The secretion of extracellular matrix (ECM) proteins with anti-tumor (Lumican) and pro-tumoral (Osteopontin, OPN) properties was shown to be dependent on the regulation of GB-induced CMA in PCs.
View Article and Find Full Text PDFFrom Waste to Worth: Upcycling Plastic into High-Value Carbon-Based Nanomaterials.
Polymers (Basel)
December 2024
Green Technology Group, Faculty of Science, Alexandria University, Alexandria 21511, Egypt.
Plastic waste (PW) presents a significant environmental challenge due to its persistent accumulation and harmful effects on ecosystems. According to the United Nations Environment Program (UNEP), global plastic production in 2024 is estimated to reach approximately 500 million tons. Without effective intervention, most of this plastic is expected to become waste, potentially resulting in billions of tons of accumulated PW by 2060.
View Article and Find Full Text PDFFormation of Adaptive Trophic Niches of Euryphagous Fish Species in Response to Off-Seasonal Water Level Regulation in Hongze Lake.
Animals (Basel)
December 2024
School of Life Science and Food Engineering, Huaiyin Institute of Technology, Huai'an 223003, China.
Off-seasonal water level regulations disrupt the biological traits and phenological rhythms of native fish species, yet their impacts on interspecific trophic interactions remain understudied. This study employed stable isotope analysis to assess the trophic dynamics of three fish species (, , and ) across different water periods in Hongze Lake. The findings revealed that all three species occupied similar mid-level trophic positions, with no significant difference among water periods ( > 0.
View Article and Find Full Text PDFHybrid prodrug nanoassembly for hypoxia-triggered immunogenic chemotherapy and immune modulation.
J Control Release
January 2025
Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China; NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, China Pharmaceutical University, Nanjing 210009, China; Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, China; State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing 210009, China. Electronic address:
Tumor hypoxia is a critical driver of cancer progression, metastasis, and therapy resistance, posing significant challenges in effective cancer treatment. Hypoxia-activable prodrugs offer a promising strategy to target tumors in low-oxygen conditions, but their efficacy is often hindered by intrinsic properties and extrinsic cues. In this study, we developed a dual-prodrug nanoassembly system (CPPA) composed of a hypoxia-triggerable camptothecin (CPT)-based dimeric prodrug (CP) and a lipid-conjugated STAT3 antisense oligonucleotide (ASO) prodrug (PA), aiming to enhance tumor-targeted chemotherapy and overcome the immune evasion within the tumor microenvironment.
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