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Cytochrome c and Ouabain Binding Site of Na,K-ATPase.
Cell Biochem Biophys
March 2025
Georgian National University, 9 Tsinandali Str., Tbilisi, Georgia.
Na,K-ATPase is an electrogenic pump found in cell plasma membranes that acts as the basic unit of animal life. This enzyme is highly susceptible to cardiotonic steroid (CTS) inhibition. The role of Na,K-ATPase in signaling has introduced a novel viewpoint regarding the enzyme's function, as the ouabain-binding site is involved in several physiological processes.
View Article and Find Full Text PDFNeonatal/infantile-onset genetic epilepsies: The utility of genetic testing for molecular etiology-specific diagnosis concerning therapeutic implications.
Epileptic Disord
March 2025
Division of Child Neurology, Department of Pediatrics, Ege University Medical Faculty, Izmir, Turkey.
Objective: To evaluate the significance of genetic testing in neonatal- and infantile-onset genetic epilepsies (NIGEP) for enhanced molecular diagnosis with management implications.
Methods: A single-center cohort of 128 patients with NIGEP (aged 0-36 months) from 2010 to 2022 was retrospectively assessed. The diagnostic utility of genetic testing, including next-generation sequencing (NGS) and chromosome-based approaches, was surveyed to determine their impact on antiseizure medication adjustments and precision medicine.
Investigating the role of eight SNPs in for COPD susceptibility in the Chinese elderly population.
Ann Med
December 2025
Department of Respiratory and Critical Care Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality among the elderly in China. Genetic predisposition is a recognized risk factor for COPD, with emerging as a promising candidate gene due to its involvement in smoking behavior and lung function. This study aimed to investigate the association between eight SNPs and COPD susceptibility in the Chinese elderly population.
View Article and Find Full Text PDFDecreased Expression of Aquaporins as a Feature of Tubular Damage in Lupus Nephritis.
Cells
March 2025
Departement of Rheumatology, Erasme-HUB Hospital, Université Libre de Bruxelles, 1070 Brussels, Belgium.
Tubulointerstitial hypoxia is a key factor for lupus nephritis progression to end-stage renal disease. Numerous aquaporins (AQPs) are expressed by renal tubules and are essential for their proper functioning. The aim of this study is to characterize the tubular expression of AQP1, AQP2 and AQP3, which could provide a better understanding of tubulointerstitial stress during lupus nephritis.
View Article and Find Full Text PDFThe Cholinergic Receptor Nicotinic α3 Was Reduced in the Hippocampus of Early Cognitively Impaired Adult Male Mice and Upregulated by Nicotine and Cytisine in HT22 Cells.
Cells
February 2025
Advanced Research Center for Geriatric and Gerontology, Akita University, Akita 010-8543, Japan.
Ageing is a major risk factor for cognitive and physical decline, but its mechanisms remain poorly understood. This study aimed to detect early cognitive and physical changes, and to analyze the pathway involved by monitoring two groups of mice: a young and an adult group. The study has identified the types of molecules involved in the hippocampus.
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