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Patterns of beta-blocker use and dose optimization among ambulatory heart failure patients with reduced ejection fraction (HFrEF) attending public hospitals in Northeast Ethiopia: a multi-center cross-sectional study.
BMC Cardiovasc Disord
January 2025
Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
Background: Evidence-based beta-blockers are essential in managing heart failure with reduced ejection fraction (HFrEF) and are known to improve cardiovascular outcomes. Despite robust nascent guideline recommendations, studies indicate that beta-blockers are often underutilized or administered below target doses. This shivery issue is particularly relevant in Ethiopia, where comprehensive evaluations of beta-blocker utilization and dosing practices are limited.
View Article and Find Full Text PDFEfficacy and application potential of purified hydrocolloid coatings sprayed onto maize seeds subjected to anti-aging.
Environ Res
January 2025
Sino-Dutch R&D Centre for Future Wastewater Treatment Technologies, Beijing Advanced Innovation Center for Future Urban Design, Beijing University of Civil Engineering and Architecture, Beijing 100044, P. R. China; Key Laboratory of Urban Stormwater System and Water Environment (Beijing University of Civil Engineering and Architecture), Ministry of Education, Beijing 100044, P. R. China. Electronic address:
The use of purified hydrocolloids extracted from waste-activated sludge has significant potential for preventing seed deterioration caused by aging. In this study, we compared the advantages and disadvantages of 3 types of purified hydrocolloid seed coatings from different waste sludges and one commercial seed coating at different spraying times (2, 4, 6, and 8). Compared with coated maize seeds, uncoated maize seeds underwent significant functional changes during the aging process according to the infrared spectroscopy results.
View Article and Find Full Text PDFConstruction and Characterization of a Mutant Library for the P Constitutive Promoter in Lactic Acid Bacteria.
J Biotechnol
January 2025
Shanghai Engineering Research Center of Food Microbiology, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China. Electronic address:
Promoters are crucial elements for controlling gene expression in cells, yet lactic acid bacteria (LAB) often lack a diverse set of available constitutive promoters with quantitative characterization. To enrich the LAB promoter library, this study focused on the known strong constitutive promoter P in LAB. Through error-prone PCR and dNTP analog-induced random mutagenesis, a library of 247 mutants of P was generated by using the red fluorescent protein (RFP) fluorescence intensity as a high-throughput screening indicator in Streptococcus thermophilus.
View Article and Find Full Text PDFCassava starch extraction with a polygalacturonase from a wild yeast strain with disintegration activity on plant tissues.
Carbohydr Res
January 2025
School of Exact, Chemical and Life Sciences, Misiones National University, Félix de Azara 1552, N3300LQH, Posadas, Misiones, Argentina.
The objective of the present study was to optimize an enzymatic starch extraction process from cassava roots using a polyglacturonase (PGase) from a wild yeast strain (Wickerhanomyces anomalus). The supernatant of W. anomalus culture, with PGase activity, was used as source of enzyme (enzymatic extract, EE).
View Article and Find Full Text PDFWaste milk consumption in dairy calves: Effects on innate immunity and inflammatory profile.
Vet Immunol Immunopathol
January 2025
Department of Internal Medicine, College of Veterinary Medicine and Animal Science, University of Sao Paulo, São Paulo, Brazil. Electronic address:
Waste milk (WM) is commonly used in calf feeding to reduce rearing costs; however, its effects on the innate immune response remain unexplored. Therefore, this study aimed to evaluate the effects of WM on the innate immune response and inflammatory profile of pre-weaned dairy calves. Thirty male Holstein calves were assigned to receive pasteurized waste milk (PWM), saleable milk (SM), and WM (n = 10 in each group).
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