Synthesis Protocols for Simple Uncharged Glycol Carbamate Nucleic Acids.

Glycol carbamate nucleic acid (GCNA) oligomers can be produced from activated carbonate monomers. The synthesized monomers can be very conveniently characterized employing analytical tools like NMR and HR-MS. Moreover, the activated carbonate monomers do not require coupling agents, and hence excess monomers can be recovered at the end of each coupling. Here we illustrate the synthesis of activated glycol carbonate monomers and their subsequent application in synthesis of carbamate oligomers.